Bioinformatics and Functional Genomics

The bestselling introduction to bioinformatics and functionalgenomics--now in an updated edition

Widely received in its previous edition, Bioinformatics andFunctional Genomics offers the most broad-based introduction tothis explosive new discipline. Now in a thoroughly updated andexpanded Second Edition, it continues to be the go-to sourcefor students and professionals involved in biomedical research.

This edition provides up-to-the-minute coverage of the fields ofbioinformatics and genomics. Features new to this editioninclude:

* Several fundamentally important proteins, such as globins,histones, insulin, and albumins, are included to better show how toapply bioinformatics tools to basic biological questions.
* A completely updated companion web site, which will beupdated as new information becomes available - visit wiley.com/go/pevsnerbioinformatics
* Descriptions of genome sequencing projects spanning the tree oflife.
* A stronger focus on how bioinformatics tools are used tounderstand human disease.

The book is complemented by lavish illustrations and more than500 figures and tables--fifty of which are entirely new tothis edition. Each chapter includes a Problem Set, Pitfalls, Boxesexplaining key techniques and mathematics/statistics principles,Summary, Recommended Reading, and a list of freely availablesoftware. Readers may visit a related Web page for supplementalinformation at wiley.com/go/pevsnerbioinformatics.

Bioinformatics and Functional Genomics, Second Editionserves as an excellent single-source textbook for advancedundergraduate and beginning graduate-level courses in thebiological sciences and computer sciences. It is also anindispensable resource for biologists in a broad variety ofdisciplines who use the tools of bioinformatics and genomics tostudy particular research problems; bioinformaticists and computerscientists who develop computer algorithms and databases; andmedical researchers and clinicians who want to understand thegenomic basis of viral, bacterial, parasitic, or otherdiseases.

Praise for the first edition:

".ideal both for biologists who want to master theapplication of bioinformatics to real-world problems and forcomputer scientists who need to understand the biological questionsthat motivate algorithms." Quarterly Review of Biology

". an excellent textbook for graduate students andupper level undergraduate students." Annals of BiomedicalEngineering

".highly recommended for academic and medicallibraries, and for researchers as an introduction andreference." E-Streams

Preface to the Second Edition.

Preface to the First Edition.

Foreword.

PART I ANALYZING DNA, RNA, AND PROTEIN SEQUENCES INDATABASES.

1 Introduction.

2 Access to Sequence Data and Literature Information.

3 Pairwise Sequence Alignment.

4 Basic Local Alignment Search Tool (BLAST).

5 Advanced Database Searching.

6 Multiple Sequence Alignment.

7 Molecular Phylogeny and Evolution.

PART II GENOMEWIDE ANALYSIS OF RNA AND PROTEIN.

8 Bioinformatic Approaches to Ribonucleic Acid (RNA).

9 Gene Expression: Microarray Data Analysis.

10 Protein Analysis and Proteomics.

11 Protein Structure.

12 Functional Genomics.

PART III GENOME ANALYSIS.

13 Completed Genomes.

14 Completed Genomes: Viruses.

15 Completed Genomes: Bacteria and Archaea.

16 The Eukaryotic Chromosome.

17 Eukaryotic Genomes: Fungi.

18 Eukaryotic Genomes: From Parasites to Primates.

19 Human Genome.

20 Human Disease.

Glossary.

Answers to Self-Test Quizzes.

Author Index.

Subject Index.