Advanced Drug Delivery

Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Provides both fundamentals and new and emerging applicationsAdvanced Drug Delivery brings readers fully up to datewith the state of the science, presenting the basics, formulationstrategies, and therapeutic applications of advanced drug delivery.The book demonstrates how core concepts of pharmaceutical scienceschemistry, and molecular biology can be combined and applied inorder to spark novel ideas to design and develop advanced drugdelivery systems for the treatment of a broad range of humandiseases.Advanced Drug Delivery features contributions from aninternational team of pharmaceutical scientists. Chapters reflect athorough review and analysis of the literature as well as theauthors' firsthand experience developing drug delivery systems. Thebook is divided into four parts:* Part I, Introduction and Basics of Advanced DrugDelivery, explores physiological barriers, stabilitytransporters, and biomaterials in drug delivery* Part II, Strategies for Advanced Drug Delivery, offerstested and proven strategies for advanced delivery of both smallmolecules and macromolecules* Part III, Translational Research of Advanced DrugDelivery, focuses on regulatory considerations andtranslational applications of advanced drug delivery systems forthe treatment of cardiovascular diseases, cancer, sexuallytransmitted diseases, ophthalmic diseases, and brain diseases* Part IV, Future Applications of Advanced Drug Delivery inEmerging Research Areas, examines stem cell researchcell-based therapeutics, tissue engineering, and molecularimagingEach chapter provides objectives and assessment questions tohelp readers grasp key concepts and assess their knowledge as theyprogress through the book.Advanced Drug Delivery is recommended for graduates andupper-level undergraduates in the pharmaceutical sciences who needa solid foundation in the basics. It is also recommended forpharmaceutical professionals who want to take advantage of new andemerging applications in advanced drug delivery systems.

PREFACE xiABOUT THE AUTHORS xiiiCONTRIBUTORS xvPART I INTRODUCTION AND BASICS OF ADVANCED DRUG DELIVERY11 Physiological Barriers in Advanced Drug Delivery:Gastrointestinal Barrier 3D. Alexander Oh and Chi H. Lee2 Solubility and Stability Aspects in Advanced Drug Delivery21Hoo-Kyun Choi, Robhash K. Subedi, and Chi H. Lee3 The Role of Transporters and the Efflux System in DrugDelivery 47Varun Khurana, Dhananjay Pal, Mukul Minocha, and Ashim K.Mitra4 Biomaterial in Advanced Drug Delivery 75Megha Barot, Mitesh Patel, Xiaoyan Yang, Wuchen Wang, and Chi H.LeePART II STRATEGIES FOR ADVANCED DRUG DELIVERY 1035 Strategies of Drug Targeting 105Ravi S. Shukla, Zhijin Chen, and Kun Cheng6 Prodrug and Bioconjugation 123Ramya Krishna Vadlapatla, Sujay Shah, Aswani Dutt Vadlapudi, andAshim K. Mitra7 Nanoscale Drug Delivery Systems 141Mitan R. Gokulgandhi, Ashaben Patel, Kishore Cholkar, MeghaBarot, and Ashim K. Mitra8 Stimuli-Responsive Target Strategies 157Chi H. Lee9 Implants 183Aswani Dutt Vadlapudi, Ashaben Patel, Ramya Krishna VadlapatlaDurga Paturi, and Ashim K. Mitra10 Aptamers in Advanced Drug Delivery 201Weiwei Gao, Omid C. Farokhzad, and Nazila Kamaly11 Nanofiber 219Megha Barot, Mitan R. Gokulgandhi, Animikh Ray, and Ashim K.Mitra12 Biomimetic Self-Assembling Nanoparticles 231Maxim G. Ryadnov13 Protein and Peptide Drug Delivery 241Mitesh Patel, Megha Barot, Jwala Renukuntla, and Ashim K.Mitra14 Delivery of Nucleic Acids 257Shaoying Wang, Bin Qin, and Kun Cheng15 Delivery of Vaccines 275Hari R. Desu, Rubi Mahato, and Laura A. ThomaPART III TRANSLATIONAL RESEARCH OF ADVANCED DRUG DELIVERY29716 Regulatory Considerations and Clinical Issues in AdvancedDrug Delivery 299Mei-Ling Chen17 Advanced Drug Delivery in Cancer Therapy 323Wanyi Tai and Kun Cheng18 Advanced Delivery in Cardiovascular Diseases 341Gayathri Acharya, Wuchen Wang, Divya Teja Vavilala, MridulMukherji, and Chi H. Lee19 Recent Advances in Ocular Drug Delivery 365Varun Khurana, Deep Kwatra, Vibhuti Agrahari, and Ashim K.Mitra20 Advanced Drug Delivery Against STD 381Chi H. Lee21 Advanced Drug Delivery to the Brain 405Nanda K. Mandava, Mitesh Patel, and Ashim K. MitraPART IV FUTURE APPLICATIONS OF ADVANCED DRUG DELIVERY INEMERGING RESEARCH AREAS 42322 Cell-Based Therapeutics 425Zhaoyang Ye, Yan Zhou, Haibo Cai, and Wen-Song Tan23 Biomedical Applications and Tissue Engineering of Collagen445Chi H. Lee and Yugyung Lee24 Molecular Imaging of Drug Delivery 469Zheng-Rong LuANSWERS 489INDEX 511