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Textbook of Influenza

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Robert G. Webster
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The Textbook of Influenza is a comprehensive resourcecovering all aspects of influenza, from the genetic and molecularbiology of the virus through to clinical aspects of the disease andthe latest drug developments and treatments. This new edition hasbeen completely revised and reflects the integration of disciplinesconcerning the emergence, evolution, pathogenesis and control ofinfluenza viruses in the field of human and veterinary publichealth.
Textbook of Influenza examines the lessons learnt fromthe latest pandemic and provides the current state of knowledge formany yet unresolved issues related to virus origin, spread,pathogenesis and disease severity to better prepare for futurepandemics. It covers the background to recent advances in influenzagenomics and reverse genetics which have allowed the identificationof virus virulence factors and the analysis and reconstruction ofinfluenza viruses such as the 1918 Spanish flu strain.

This new edition is divided into eight key sections, containingchapters co-written by international experts from both the clinicaland scientific communities, covering:
* Influenza Perspectives
* Structure and Replication
* Evolution and Ecology
* Epidemiology and Surveillance
* Immunology
* Vaccines and Vaccine Development
* Clinical Aspects and Antivirals
* Public Health

Textbook of Influenza is for all those working in thearea of influenza including clinical and basic scientists,immunologists, molecular and structural virologists, public healthofficials and global pandemic control planners.
List of contributors, ix

Foreword to the second edition, xiv

Preface to the second edition, xvi

Acknowledgments, xvii

PART 1 Influenza: Perspective

1 Human influenza: One health, one world, 3
Daniel B. Jernigan and Nancy J. Cox

2 Influenza pandemics: History and lessons learned, 20
Arnold S. Monto and Robert G. Webster

PART 2 Structure and replication

3 Structure, disassembly, assembly, and budding of influenzaviruses, 37
Debiprosad Nayak, Sakar Shivakoti, Rilwan A. Balogun, GwendolynLee, and Z. Hong Zhou

4 The virus genome and its replication, 57
Robert M. Krug and Ervin Fodor

5 Influenza glycoproteins: Hemagglutinin and neuraminidase,67
Rupert J. Russell, Steven J. Gamblin, and John J. Skehel

6 Proton channels of influenza A and B viruses, 101
Chunlong Ma, Lawrence H. Pinto, and Robert A. Lamb

7 The NS1 protein: A master regulator of host and viralfunctions, 114
Robert M. Krug and Adolfo García-Sastre

8 Structure and function of the influenza virus replicationmachinery and PB1-F2, 133
Andrew Mehle and Jonathan A McCullers

9 The genome and its manipulation: Recovery of the 1918 virusand vaccine virus generation, 146
Gabriele Neumann and Yoshihiro Kawaoka

10 Pathogenesis, 157
Hans Dieter Klenk, Wolfgang Garten, and MikhailMatrosovich

PART 3 Evolution and ecology of influenza viruses

11 Ecology and evolution of influenza viruses in wild anddomestic birds, 175
Ron A.M. Fouchier and Yi Guan

12 Influenza in swine, 190
Richard Webby and Juergen Richt

13 Equine/Canine/Feline/Seal influenza, 203
Thomas M. Chambers, Edward J. Dubovi, and Ruben O. Donis

14 Emergence and Evolution of the 1918, 1957, 1968, and 2009pandemic virus strains, 218
Taia T. Wang and Peter Palese

PART 4 Epidemiology and surveillance

15 Influenza surveillance and laboratory diagnosis, 231
Maria Zambon

16 Epidemiology of influenza, 250
Marc-Alain Widdowson and Arnold S. Monto

PART 5 Immunology of influenza

17 Innate immunity, 269
Akiko Iwasaki and Malik Peiris

18 Antibody-mediated immunity, 283
Nicole Baumgarth,Michael C. Carroll, and SantiagoGonzalez

19 Cell-mediated immunity, 298
Stephen J. Turner, Peter C. Doherty, and Anne Kelso

PART 6 Vaccines and vaccine development

20 Immunogenicity, efficacy of inactivated/live virus seasonaland pandemic vaccines, 313
Wendy A. Keitel, Kathleen M. Neuzil, and John Treanor

21 New approaches to vaccination, 327
Chih-Jen Wei, Damian C. Ekiert, Gary J. Nabel, and Ian A.Wilson

22 Control of influenza in animals, 337
Ilaria Capua and Dennis J. Alexander

23 Influenza vaccine production, 352
Klaus Stöhr

PART 7 Clinical aspects and antivirals

24 Human influenza: Pathogenesis, clinical features, andmanagement, 373
Frederick G. Hayden and Menno D. de Jong

25 Antivirals: Targets and use, 392
Michael G. Ison and Alan Hay

26 The control of influenza and cost-effectiveness ofinterventions, 419
Carolyn B. Bridges, Samuel K. Peasah, and Martin I.Meltzer

27 Applications of quantitative modeling to influenza virustransmission dynamics, antigenic and genetic evolution, andmolecular structure, 434
Marc Lipsitch and Derek Smith

28 Pandemic preparedness and response, 453
Jonathan S. Nguyen-Van-Tam and Joseph Bresee

29 Influenza: The future, 470
Thomas J. Braciale

PART 8 The outbreak of H7N9

30 Appendix, 479
Thomas J. Bracial