Textbook of Influenza

The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: Influenza Perspectives Structure and Replication Evolution and Ecology Epidemiology and Surveillance Immunology Vaccines and Vaccine Development Clinical Aspects and Antivirals Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.

The Textbook of Influenza is a comprehensive resourcecovering all aspects of influenza, from the genetic and molecularbiology of the virus through to clinical aspects of the disease andthe latest drug developments and treatments. This new edition hasbeen completely revised and reflects the integration of disciplinesconcerning the emergence, evolution, pathogenesis and control ofinfluenza viruses in the field of human and veterinary publichealth.Textbook of Influenza examines the lessons learnt fromthe latest pandemic and provides the current state of knowledge formany yet unresolved issues related to virus origin, spreadpathogenesis and disease severity to better prepare for futurepandemics. It covers the background to recent advances in influenzagenomics and reverse genetics which have allowed the identificationof virus virulence factors and the analysis and reconstruction ofinfluenza viruses such as the 1918 Spanish flu strain.This new edition is divided into eight key sections, containingchapters co-written by international experts from both the clinicaland scientific communities, covering:* Influenza Perspectives* Structure and Replication* Evolution and Ecology* Epidemiology and Surveillance* Immunology* Vaccines and Vaccine Development* Clinical Aspects and Antivirals* Public HealthTextbook of Influenza is for all those working in thearea of influenza including clinical and basic scientistsimmunologists, molecular and structural virologists, public healthofficials and global pandemic control planners.

List of contributors, ixForeword to the second edition, xivPreface to the second edition, xviAcknowledgments, xviiPART 1 Influenza: Perspective1 Human influenza: One health, one world, 3Daniel B. Jernigan and Nancy J. Cox2 Influenza pandemics: History and lessons learned, 20Arnold S. Monto and Robert G. WebsterPART 2 Structure and replication3 Structure, disassembly, assembly, and budding of influenzaviruses, 37Debiprosad Nayak, Sakar Shivakoti, Rilwan A. Balogun, GwendolynLee, and Z. Hong Zhou4 The virus genome and its replication, 57Robert M. Krug and Ervin Fodor5 Influenza glycoproteins: Hemagglutinin and neuraminidase,67Rupert J. Russell, Steven J. Gamblin, and John J. Skehel6 Proton channels of influenza A and B viruses, 101Chunlong Ma, Lawrence H. Pinto, and Robert A. Lamb7 The NS1 protein: A master regulator of host and viralfunctions, 114Robert M. Krug and Adolfo García-Sastre8 Structure and function of the influenza virus replicationmachinery and PB1-F2, 133Andrew Mehle and Jonathan A McCullers9 The genome and its manipulation: Recovery of the 1918 virusand vaccine virus generation, 146Gabriele Neumann and Yoshihiro Kawaoka10 Pathogenesis, 157Hans Dieter Klenk, Wolfgang Garten, and MikhailMatrosovichPART 3 Evolution and ecology of influenza viruses11 Ecology and evolution of influenza viruses in wild anddomestic birds, 175Ron A.M. Fouchier and Yi Guan12 Influenza in swine, 190Richard Webby and Juergen Richt13 Equine/Canine/Feline/Seal influenza, 203Thomas M. Chambers, Edward J. Dubovi, and Ruben O. Donis14 Emergence and Evolution of the 1918, 1957, 1968, and 2009pandemic virus strains, 218Taia T. Wang and Peter PalesePART 4 Epidemiology and surveillance15 Influenza surveillance and laboratory diagnosis, 231Maria Zambon16 Epidemiology of influenza, 250Marc-Alain Widdowson and Arnold S. MontoPART 5 Immunology of influenza17 Innate immunity, 269Akiko Iwasaki and Malik Peiris18 Antibody-mediated immunity, 283Nicole Baumgarth,Michael C. Carroll, and SantiagoGonzalez19 Cell-mediated immunity, 298Stephen J. Turner, Peter C. Doherty, and Anne KelsoPART 6 Vaccines and vaccine development20 Immunogenicity, efficacy of inactivated/live virus seasonaland pandemic vaccines, 313Wendy A. Keitel, Kathleen M. Neuzil, and John Treanor21 New approaches to vaccination, 327Chih-Jen Wei, Damian C. Ekiert, Gary J. Nabel, and Ian A.Wilson22 Control of influenza in animals, 337Ilaria Capua and Dennis J. Alexander23 Influenza vaccine production, 352Klaus StöhrPART 7 Clinical aspects and antivirals24 Human influenza: Pathogenesis, clinical features, andmanagement, 373Frederick G. Hayden and Menno D. de Jong25 Antivirals: Targets and use, 392Michael G. Ison and Alan Hay26 The control of influenza and cost-effectiveness ofinterventions, 419Carolyn B. Bridges, Samuel K. Peasah, and Martin I.Meltzer27 Applications of quantitative modeling to influenza virustransmission dynamics, antigenic and genetic evolution, andmolecular structure, 434Marc Lipsitch and Derek Smith28 Pandemic preparedness and response, 453Jonathan S. Nguyen-Van-Tam and Joseph Bresee29 Influenza: The future, 470Thomas J. BracialePART 8 The outbreak of H7N930 Appendix, 479Thomas J. Bracial