Vaccinology

Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.

Vaccinology: An Essential Guide outlines in a clearpractical format the entire vaccine development process, fromconceptualization and basic immunological principles through toclinical testing and licensing of vaccines. With anoutstanding introduction to the history and practice ofvaccinology, it also guides the reader through the basic sciencerelating to host immune responses to pathogens.Covering the safety, regulatory, ethical, and economicand geographical issues that drive vaccine development and trialsit also presents vaccine delivery strategies, novel vaccineplatforms (including experimental vaccines and pathogens), antigendevelopment and selection, vaccine modelling, and the developmentof vaccines against emerging pathogens and agents of bioterror.There are also sections devoted to veterinary vaccines andassociated regulatory processes.Vaccinology: An Essential Guide is a perfect tool fordesigned for undergraduate and graduate microbiologists andimmunologists, as well as residents, fellows and trainees ofinfectious disease and vaccinology. It is also suitable for allthose involved in designing and conducting clinical vaccine trialsand is the ideal companion to the larger reference bookVaccinology: Principles and Practice.

Contributors viiPreface ix1 The history of vaccine development and the diseases vaccines prevent 1Martin G. Myers2 The vaccine development pathway 33David W.C. Beasley3 Control and eradication of human and animal diseases by vaccination 43Nigel Bourne and Gregg N. Milligan4 Pathogenesis of infectious diseases and mechanisms of immunity 59Jere W. McBride and David H. Walker5 The host immune response protective immunity and correlates of protection 73Gregg N. Milligan6 Adjuvants: making vaccines immunogenic 93Gregg N. Milligan7 Discovery and the basic science phase of vaccine development 109Gavin C. Bowick8 Microbial-based and material-based vaccine delivery systems 127Alfredo G. Torres, Jai S. Rudra and Gregg N. Milligan9 Licensed vaccines for humans 152Alan D.T. Barrett10 Veterinary vaccines 181A. Paige Adams11 Development of vaccines for microbial diseases 192Dennis W. Trent and David W.C. Beasley12 The regulatory path to vaccine licensure 212Dennis W. Trent13 Veterinary vaccines: regulations and impact on emerging infectious diseases 232A. Paige Adams14 Vaccine manufacturing 243Dirk E. Teuwen and Alan D.T. Barrett15 Clinical evaluation of vaccines 260Richard E. Rupp and Bridget E. Hawkins16 Vaccine recommendations and special populations 273Richard E. Rupp and Bridget E. Hawkins17 Vaccine safety 287Dirk E. Teuwen and Alan D.T. Barrett18 Understanding and measuring the dynamics of infectious disease transmission 304Christine M. Arcari19 Vaccines from a global perspective 319Alan D.T. Barrett and Bridget E. Hawkins20 Political ethical social and psychological aspects of vaccinology 335Caroline M. Poland, Robert M. Jacobson, Douglas J. Opel, Edgar K. Marcuse and Gregory A. PolandIndex 358