Nanoparticulate Drug Delivery Systems

Frank discussions of opportunities and challenges point the way to new, more effective drug delivery systems Interest in nanomedicine has grown tremendously, fueled by the expectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agents to human tissues and organs. The field, however, has faced several challenges attempting to translate novel ideas into clinical benefits. With contributions from an international team of leading nanomedicine researchers, this book provides a practical assessment of the possibilities and the challenges of modern nanomedicine that will enable the development of clinically effective nanoparticulate drug delivery products and systems. Nanoparticulate Drug Delivery Systems focuses on the rationales and preclinical evaluation of new nanoparticulate drug carriers that have yet to be thoroughly reviewed in the literature. The first chapter sets the stage with a general overview of targeted nanomedicine. The book then explores new and promising nanoparticulate drug delivery systems, including: Lipid nanoparticles for the delivery of nucleic acids Multifunctional dendritic nanocarriers Polymer drug nanoconjugates Next, the book presents new opportunities and challenges for nanoparticulate drug delivery systems, including: Clearance of nanoparticles during circulation Drug delivery strategies for combatting multiple drug resistance Toxicological assessment of nanomedicine Chapters offer state-of-the-technology reviews with extensive references to facilitate further investigation. Moreover, each chapter concludes with an expert assessment of remaining challenges, pointing the way to solutions and new avenues of research. With its frank discussions of opportunities and challenges, Nanoparticulate Drug Delivery Systems sets a solid foundation for new research leading to the discovery and development of better nanomedicines.

Frank discussions of opportunities and challenges pointthe way to new, more effective drug delivery systemsInterest in nanomedicine has grown tremendously, fueled by theexpectation that continued research will lead to the safeefficient, and cost-effective delivery of drugs or imaging agentsto human tissues and organs. The field, however, has faced severalchallenges attempting to translate novel ideas into clinicalbenefits. With contributions from an international team of leadingnanomedicine researchers, this book provides a practical assessmentof the possibilities and the challenges of modern nanomedicine thatwill enable the development of clinically effective nanoparticulatedrug delivery products and systems.Nanoparticulate Drug Delivery Systems focuses on therationales and preclinical evaluation of new nanoparticulate drugcarriers that have yet to be thoroughly reviewed in the literature.The first chapter sets the stage with a general overview oftargeted nanomedicine. The book then explores new and promisingnanoparticulate drug delivery systems, including:* Lipid nanoparticles for the delivery of nucleic acids* Multifunctional dendritic nanocarriers* Polymer drug nanoconjugatesNext, the book presents new opportunities and challenges fornanoparticulate drug delivery systems, including:* Clearance of nanoparticles during circulation* Drug delivery strategies for combatting multiple drugresistance* Toxicological assessment of nanomedicineChapters offer state-of-the-technology reviews with extensivereferences to facilitate further investigation. Moreover, eachchapter concludes with an expert assessment of remainingchallenges, pointing the way to solutions and new avenues ofresearch.With its frank discussions of opportunities and challengesNanoparticulate Drug Delivery Systems sets a solidfoundation for new research leading to the discovery anddevelopment of better nanomedicines.

Preface viiContributors ix1 Tumor-Targeted Nanoparticles: State-of-the-Art and RemainingChallenges 1Gaurav Bajaj and Yoon Yeo2 Applications of Ligand-Engineered Nanomedicines 21Gayong Shim, Joo Yeon Park, Lee Dong Roh, Yu-Kyoung Oh, andSangbin Lee3 Lipid Nanoparticles for the Delivery of Nucleic Acids 51Yuhua Wang and Leaf Huang4 Photosensitive Liposomes as Potential Targeted TherapeuticAgents 81David H. Thompson, Pochi Shum, Oleg V. Gerasimov, and MarquitaQualls5 Multifunctional Dendritic Nanocarriers: The Architecture andApplications in Targeted Drug Delivery 101Ryan M. Pearson, Jin Woo Bae, and Seungpyo Hong6 Chitosan-Based Nanoparticles for Biomedical Applications129Heebeom Koo, Kuiwon Choi, Ick Chan Kwon, and KwangmeyungKim7 Polymer-Drug Nanoconjugates 151Rong Tong, Li Tang, Nathan P. Gabrielson, Qian Yin, and JianjunCheng8 Nanocrystals Production, Characterization, and Application forCancer Therapy 183Christin P. Hollis and Tonglei Li9 Clearance of Nanoparticles During Circulation 209Seung-Young Lee and Ji-Xin Cheng10 Drug Delivery Strategies for Combating Multiple DrugResistance 241Joseph W. Nichols and You Han Bae11 Intracellular Trafficking of Nanoparticles: Implications forTherapeutic Efficacy of the Encapsulated Drug 261Lin Niu and Jayanth Panyam12 Toxicological Assessment of Nanomedicine 281Hayley Nehoff, Sebastien Taurin, and Khaled GreishIndex 307