Non-Alcoholic Fatty Liver Disease

The sharp rise in cases of Non-alcoholic fatty liver disease is fast becoming one of the major concerns for hepatologists worldwide. This comprehensive clinical guide explains how to diagnose NAFLD and manage patients according to the best standards of care. Contributors from the world's leading institutions concentrate on patient care, drawing on their extensive experience.

The sharp rise in cases of Non-alcoholic fatty liver disease is fast becoming one of the major concerns for hepatologists worldwide. This comprehensive clinical guide explains how to diagnose NAFLD and manage patients according to the best standards of care. Contributors from the world's leading institutions concentrate on patient care, drawing on their extensive experience.

List of Contributors, vii1 What is non-alcoholic fatty liver disease (NAFLD), and why isit important? 1Geoffrey C. Farrell, Arthur J. McCullough, and Christopher P.Day2 NAFLD in the community, 17Leon A. Adams3 Pathology of NAFLD, 27Elizabeth M. Brunt and David E. Kleiner4 The natural history of NAFLD, 37Paul Angulo5 Emerging concepts on the pathogenesis of non-alcoholicsteatohepatitis (NASH), 46Isabelle A. Leclercq6 Diabetes and NAFLD: why is the connection important? 62Elisabetta Bugianesi7 NAFLD and cardiovascular risk factors: implications forvascular disease, 71Giovanni Targher8 A primary care perspective of fatty liver: diagnosismanagement, prescribing, and when to refer, 84Shivakumar Chitturi and Geoffrey C. Farrell9 Imaging of NAFLD, 93Takeshi Yokoo, An Tang, and Claude B. Sirlin10 Non-invasive methods to determine the severity of NAFLD andNASH, 112Vincent Wai-Sun Wong and Henry Lik-Yuen Chan11 Fatigue, quality of life, and psychosocial issues for peoplewith NAFLD, 122Julia L. Newton and James Frith12 Physical activity and cardiovascular fi tness in patientswith NAFLD: clinical importance and therapeutic implications132Ingrid J. Hickman, Graeme A. Macdonald, and Nuala M.Byrne13 NAFLD, obesity, and bariatric surgery, 149Philippe Mathurin14 Genetic predisposition to NAFLD and NASH: implications forpathogenesis, diagnosis, prevention, and management, 157Quentin M. Anstee, Ann K. Daly, and Christopher P. Day15 NAFLD in children, 171Ariel E. Feldstein16 The pointy end of the NAFLD iceberg: cirrhosis, portalhypertension, and liver failure, 182Jonathon W. Schwake, Dawn M. Torres, and Stephen A.Harrison17 Non-alcoholic fatty liver disease, hepatocellular cancer, andother cancers, 192Janine Graham and Helen L. Reeves18 NAFLD in Chinese and South Asian people, 206Jia-Horng Kao, Deepak Amarapurkar, and Jian-Gao Fan19 Non-alcoholic fatty liver disease in Japan, 217Takeshi Okanoue, Kohichiroh Yasui, and Yoshito Itoh20 Non-alcoholic fatty liver disease in South America andHispanic people, 228Helma Pinchemel Cotrim and Carla Daltro21 Alcohol in non-alcoholic fatty liver disease: an oxymoron ora new standard of care?, 234Achuthan Sourianarayanane, Srinivasan Dasarathy, and Arthur J.McCullough22 Dietary factors in the pathogenesis and care of patients withfatty liver disease, 248Giulio Marchesini, Rebecca Marzocchi, Anna S. SasdelliCristiana Andruccioli, and Silvia Di Domizio23 Metabolic factors and steatosis in patients with hepatitis Band C, 260Francesco Negro24 Drug therapy for NASH: insulin-sensitizing agents (metforminand thiazolidinediones), 271Mohammad S. Siddiqui and Arun J. Sanyal25 Hepatoprotectants against fatty liver disease: antioxidantsursodeoxycholic acid, and herbal medicines, 284Anne Catherine Bürgi and Jean-François Dufour26 Lipid modifiers and NASH: statins, ezetimibe, fibrates, andother agents, 293Giovanni Musso, Federica Molinaro, Elena Paschetta, RobertoGambino, and Maurizio CassaderIndex, 308Color plate section facing p86