Hemophilia and Hemostasis

There is a general need amongst healthcare professionals for practical advice on the management of patients with bleeding disorders. This book is an essential resource for all those working in the fields of coagulation, hemostasis and thrombosis. It covers the major cases one might encounter in diagnosing, managing and treating hemophilia and hemostasis. It provides a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders. The book is divided into major chapter sections depending on the type of bleeding disorder it fits into. Each chapter includes a brief overview of the disorder covering: history of the disorder; molecular basis of the disorder; class presentation; genetics; current laboratory tests and monitoring. Cases associated with each disorder are presented alongside practical questions and answers from a wide range of contributors. As practice can vary from center to center, controversial areas are clearly marked and discussed throughout. New to this edition: coverage of the newer techniques; newer treatment modalities; new oral anticoagulants; update on hemophilia management; more on ITP and greater coverage of new cases as suggested by reviewers.

There is a general need amongst healthcare professionals for practical advice on the management of patients with bleeding disorders. This book is an essential resource for all those working in the fields of coagulation, hemostasis and thrombosis. It covers the major cases one might encounter in diagnosing, managing and treating hemophilia and hemostasis. It provides a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders.The book is divided into major chapter sections depending on the type of bleeding disorder it fits into. Each chapter includes a brief overview of the disorder covering: history of the disorder; molecular basis of the disorder; class presentation; genetics; current laboratory tests and monitoring. Cases associated with each disorder are presented alongside practical questions and answers from a wide range of contributors. As practice can vary from center to center, controversial areas are clearly marked and discussed throughout.New to this edition: coverage of the newer techniques; newer treatment modalities; new oral anticoagulants; update on hemophilia management; more on ITP and greater coverage of new cases as suggested by reviewers.

List of ContributorsForewordSECTION 1: HAEMOPHILIA A AND HAEMOPHILIA BGeneral OverviewThe hemophilic ankle: an updateThe haemophilic knee: An updateHaemophilia with InhibitorsInhibitor patient requiring high dose therapy with rVIIa as wellas sequential therapy with FEIBA.Prophylactic therapy in a patient with a high titerinhibitorImmune Tolerance InductionMonitoring during ITIFIX inhibitorsSevere Hemophilia B with high response inhibitor andanaphylactic reaction to factor IXInhibitor patient and dental surgeryHaemophilic treatment for proceduresDVT prophylaxis in patients with hemophilia A undergoingorthopedic surgeryProstate Surgery and HemophiliaMild Hemophilia and Intraocular InjectionsEndoscopy/colonoscopy and HemophiliaDialysis and HemophiliaCircumcisionPK Studies prior to Orthopedic SurgeryCompartment SyndromeSuccessful eradication of factor VIII inhibitor in patient withmild Hemophilia A prior tohemipelvectomy for extensive hemophilic pseudotumorCoronary artery disease and hemophiliaValve Replacement and HemophiliaTreatment for other conditionsThyroid biopsy and HemophiliaAtrial Fibrillation and bleeding disordersChronic Upper GI bleeding and hemophiliaHematuriaOther issues in haemophilia careReproductive Options for Hemophilia A CarriersMild Hemophilia A with Discrepant FVIII activity levelsCompund DiagnosesHemophilia A with tuberous sclerosis and CNS bleedFamilial Risk Assessment for Individuals with Hemophilia A andvon Willebrand DiseaseHemophilia A and HHTSECTION 2: VON WILLEBRAND DISEASEManagement during proceduresType I VWD TonsillectomyVWD and Dental surgeryVWD and GI surgeryVWD and Obstetric/Gynecologic ProceduresRare forms of Von WillebrandDiseaseType 2A VWD and recurrent GI bleedingType 2B VWD and Thoracic SurgeryVon Willebrand disease 2NSECTION 3: OTHER BLEEDING DISORDERSProthrombin deficiencyFactor V deficiencyFactor VII deficiencyFX deficiencyFactor XI deficiencyFactor XIII deficiencyCombined factor V and factor VIII deficiency 1, 2Glanzmann ThrombaestheniaGardner-Diamond syndrome and VWDQualitative Platelet Disorder--QPDSECTION 4: ACQUIRED BLEEDING DISORDERSAcquired FVIII inhibitor and B cell neoplasmFVIII inhibitor and lupus inhibitorAcquired VWDA woman with bleeding gumsBleeding after cardiac surgeryBleeding in a dialysis patientA woman with anemia and hematuriaScalp bleeding in an older gentlemanHyperfibrinolysisSECTION 5: THROMBOTIC DISORDERSHeparin induced thrombocytopenia with thrombosisHeparin Skin NecrosisWarfarin skin necrosisThoracic outlet syndrome 3, 4Antithrombin DeficiencyMay-Thurner syndromeThrombosis in a liver transplant patientCombined thrombophiliaIndex