Neuroinflammation and CNS Disorders

The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches. The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system. Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field.

The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches.The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system.Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field.

List of Contributors viiPreface xiiiIntroduction xvAbout the Companion Website xxi1 Immune Privilege of the Brain 1Ingo Bechmann and Nicola Woodroofe2 Innate Immunity in the CNS - A Focus on the Myeloid Cell 9Craig S. Moore, Bryce A. Durafourt and Jack P. Antel3 Adaptive Immune Responses in the CNS 37David Male4 Ageing and the Immune Response in the CNS 59Divya D.A. Raj, Bart J.L. Eggen and Hendrikus W.G.M. Boddeke5 Brain Repair: The Role of Endogenous and Transplanted Neural Stem Cells 89Marco Bacigaluppi, Erica Butti, Cecilia Laterza, Donatella De Feo, Luca Peruzzotti, Arianna Merlini, Melania Cusimano and Gianvito Martino6 Neuroinflammation in Alzheimer's, Parkinson's and Huntington's Diseases 111Magdalena Sastre, Loukia Katsouri, Amy Birch, Alexander Renziehausen, David T. Dexter, Robert R. Crichton and Roberta J. Ward7 CNS Infections 151S. Louise Cosby, Sareen Galbraith and Derek Healy8 Neuroimmunology of Amyotrophic Lateral Sclerosis 185Jenny S. Henkel, David R. Beers, Weihua Zhao and Stanley H. Appel9 Demyelinating Disorders of the CNS 211Laura Peferoen, Moniek Kattenbelt, Lenthe Lodder, Paul van der Valk, Johannes M. van Noort and Sandra Amor10 Other Autoimmune Disorders: Systemic Lupus Erythematosus, Primary Sj¨ogren's Syndrome, Gluten-related Neurological Dysfunction and Paraneoplastic Neurological Syndromes 235Marios Hadjivassiliou11 Inflammation in the Pathogenesis of Depression 261Thomas J. Connor and Andrew Harkin12 Immune Responses in the CNS in Epilepsy 289Jan Bauer, Bethan Lang, Sarosh R. Irani and Annamaria Vezzani13 Inflammatory Mediators and Dysfunction of the Neurovascular Unit following Ischaemia Reperfusion 317Philip A. Barber14 Spinal Cord Injury 339John C. Gensel15 Immune Responses to Tumours in the CNS 363Paul Gielen, Paul van der Valk and Pieter WesselingIndex 385