Dendrimer-Based Drug Delivery Systems

The opportunities and challenges of using dendrimers to improve drug delivery Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication to targeted human organs. With contributions from an international team of pioneers and experts in dendrimer research, this book provides a comprehensive overview of the latest research efforts in designing and optimizing dendrimer-based drug delivery systems. The book analyzes key issues, demonstrating the critical connections that link fundamental concepts, design, synthesis, analytical methodology, and biological assessment to the practical use of dendrimers in drug delivery applications. Topics covered include: Dendrimer history Synthesis Physicochemical properties Principles of drug delivery Applications in diverse biomedical fields Dendrimer-Based Drug Delivery Systems reflects the authors' thorough review and analysis of the current literature as well as their own firsthand experience in the lab. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research. References at the end of each chapter serve as a gateway to the growing body of literature in the field, enabling readers to explore each individual topic in greater depth. Pharmaceutical and biomedical researchers will find this book a unique and essential guide to the opportunities, issues, and challenges involved in fully exploiting the potential of dendrimers to improve drug delivery.

The opportunities and challenges of using dendrimers to improvedrug deliveryAmong pharmaceutical and biomedical researchers, the use ofdendrimers in drug delivery systems has attracted increasinginterest. In particular, researchers have noted that the volume ofa dendrimer increases when it has a positive charge. If thisproperty can be applied effectively, dendrimers have enormouspotential in drug delivery systems, directly supplying medicationto targeted human organs.With contributions from an international team of pioneers andexperts in dendrimer research, this book provides a comprehensiveoverview of the latest research efforts in designing and optimizingdendrimer-based drug delivery systems. The book analyzes keyissues, demonstrating the critical connections that linkfundamental concepts, design, synthesis, analytical methodologyand biological assessment to the practical use of dendrimers indrug delivery applications. Topics covered include:* Dendrimer history* Synthesis* Physicochemical properties* Principles of drug delivery* Applications in diverse biomedical fieldsDendrimer-Based Drug Delivery Systems reflects theauthors' thorough review and analysis of the current literature aswell as their own firsthand experience in the lab. Readers will notonly discover the current state of the science, but also gainvaluable insights into fruitful directions for future research.References at the end of each chapter serve as a gateway to thegrowing body of literature in the field, enabling readers toexplore each individual topic in greater depth.Pharmaceutical and biomedical researchers will find this book aunique and essential guide to the opportunities, issues, andchallenges involved in fully exploiting the potential of dendrimersto improve drug delivery.

Foreword viiDonald A. TomaliaPreface ixAcknowledgments xiContributors xiiiAbout the Editor xvii1 Dendrimer Chemistry: Supramolecular Perspectives andApplications 1Charles N. Moorefield, Sujith Perera, and George R.Newkome2 Physicochemical Properties of Dendrimers and DendrimerComplexes 55Toyoko Imae3 The Use of Dendrimers to Optimize the Physicochemical andTherapeutic Properties of Drugs 93Nicole Stieger, Wilna Liebenberg, Marique E. Aucamp, andMelgardt M. de Villiers4 Biological Properties of Phosphorus Dendrimers 139Anne-Marie Caminade and Jean-Pierre Majoral5 Dendrimer-Based Prodrugs: Synthesis and Biological Evaluation157Mohammad Najlah, Zhengyuan Zhou, and AntonyD'Emanuele6 Improving the Biocompatibility of Dendrimers in Drug Delivery207Yiwen Li, Libo Zhao, and Yiyun Cheng7 Degradable Dendrimers for Drug Delivery 239Marc Gingras and Myriam Roy8 Design of Stimuli-Responsive Dendrimers for BiomedicalPurposes 307Chie Kojima9 Dendrimer-Based Gene Delivery Systems: Administration Routesand In Vivo Evaluation 329Santander-Ortega M.J., Uchegbu I.F., and Scha¨tzleinA.G.10 Triazine Dendrimers for DNA and siRNA Delivery: ProgressChallenges, and Opportunities 355Meredith A. Mintzer, Olivia M. Merkel, Thomas Kissel, and EricE. Simanek11 Dendrimer-Coated Carbohydrate Residues as Drug DeliveryTrojan Horses in Glycoscience 407Yoann M. Chabre and Rene´ Roy12 Nuclear Magnetic Resonance Techniques in the Analysis ofPamam Dendrimer-Based Drug Delivery Systems 439Xueyan Feng, Kun Yang, Jingjing Hu, Tongwen Xu, and YiyunCheng13 Dendrimer-Based Medical Nanodevices for Magnetic ResonanceImaging Applications 463Hongdong Cai, Mingwu Shen, and Xiangyang Shi14 Dendrimer-Related Nanoparticle System for Computed TomographyImaging 479Chen Peng and Xiangyang ShiIndex 501