Biomimetic, Bioresponsive, and Bioactive Materials

The accessible introduction to biomaterials and their applications in tissue replacement, medical devices, and more Molecular and cell biology is being increasingly integrated into the search for high-performance biomaterials and biomedical devices, transforming a formerly engineering- and materials science based field into a truly interdisciplinary area of investigation. Biomimetic, Bioresponsive, and Bioactive Materials presents a comprehensive introduction to biomaterials, discussing how they are selected, designed, and modified for integration with living tissue and how they can be utilized in the development of medical devices, orthopedics, and other related areas. Examining the physico chemical properties of widely used biomaterials and their uses in different clinical fields, the book explores applications including soft and hard tissue replacement; biointeractive metals, polymers, and ceramics; and in vitro, in vivo, and ex vivo biocompatibility tests and clinical trials. The book critically assesses the clinical level of research in the field, not only presenting proven research, but also positing new avenues of exploration. Biomimetic, Bioresponsive, and Bioactive Materials contains everything needed to get a firm grasp on materials science, fast. Written in an accessible style and including practice questions that test comprehension of the material covered in each chapter, the book is an invaluable tool for students as well as professionals new to the field.

The accessible introduction to biomaterials and theirapplications in tissue replacement, medical devices, andmoreMolecular and cell biology is being increasingly integrated intothe search for high-performance biomaterials and biomedicaldevices, transforming a formerly engineering- and materialsscience-based field into a truly interdisciplinary area ofinvestigation. Biomimetic, Bioresponsive, and Bioactive Materialspresents a comprehensive introduction to biomaterials, discussinghow they are selected, designed, and modified for integration withliving tissue and how they can be utilized in the development ofmedical devices, orthopedics, and other related areas.Examining the physico chemical properties of widely usedbiomaterials and their uses in different clinical fields, the bookexplores applications including soft and hard tissue replacement;biointeractive metals, polymers, and ceramics; and in vitro, invivo, and ex vivo biocompatibility tests and clinical trials. Thebook critically assesses the clinical level of research in thefield, not only presenting proven research, but also positing newavenues of exploration.Biomimetic, Bioresponsive, and Bioactive Materials containseverything needed to get a firm grasp on materials science, fast.Written in an accessible style and including practice questionsthat test comprehension of the material covered in each chapterthe book is an invaluable tool for students as well asprofessionals new to the field.

Chapter 1. History of Biomimetic, Bioactive and Bioresponsive Biomaterials (Matteo Santin and Gary Phillips).1.1 The first generation of biomaterials: the search for 'the bioinert'.1.2 Second-generation of biomaterials: biomimetic, bioresponsive, bioactive.1.3 The third-generation biomaterials: biomimicking natural bioactive and bioresponsive processes.1.4 Principles of biomimesis and bioactivity.1.5 Bioactive biomaterials from different natural sources.1.6 Scope of this book.1.7 Exercises/Questions Chapter 1.1.8 References.Chapter 2. Soft Tissue Structure and Functionality (Gabriela Voskerician).2.1 Overview.2.2 Epithelial Tissue.2.3 The Skin.2.4 Muscle Tissue.2.5 Connective Tissue.2.6 The Foreign Body Response.2.7 Exercises/Questions Chapter 2.2.8 References.Chapter 3. Hard Tissues Structures and Functionality (Antonio Merolli and Paolo Tranquilli Leali).3.1 Definition of hard tissues.3.2 Articular cartilage.3.3 Bone tissue.3.4 Conclusive remarks.3.5 Exercises/Questions Chapter 3.3.6 References.Chapter 4. Biomedical Applications of Biomimetic Polymers: The Phosphorylcholine-Containing Polymers (Andrew L. Lewis and Andrew W. Lloyd).4.1 Historical Perspective.4.2 Synthesis of Pc-containing Polymers.4.3 Physicochemical Properties of PC-containing Polymers.4.4 Stability and Mechanical Property Considerations.4.5 Biological Compatibility.4.6 Applications of PC Polymers.4.7 Summary.4.8 Exercises/Questions Chapter 4.4.9 References.Chapter 5. Biomimetic, Bioresponsive, and Bioactive Materials: Integrating Materials with Tissue (Roberto Chiesa and Alberto Cigada).5.1 Introduction.5.2 Mandatory requirements for metals as implantable materials.5.3 Biocompatibility of metals.5.4 Surface treatments of metals for biomedical applications.5.5 Exercises/Questions Chapter 5.5.6 References.Chapter 6. Ceramics (Montserrat Espanol, Román A. Pérez, Edgar B. Montufar, Maria-Pau Ginebra).6.1 Historical perspective.6.2 Biostable ceramics.6.3 Bioactive and resorbable ceramics.6.4 Exercises/Questions Chapter 6.6.5 References.Chapter 7. Biofunctional Biomaterials of the Future (Mario Barbosa, Gary Phillips, Matteo Santin).7.1 Clinically led generation biomaterials.7.2 Biomacromolecule-inspired biomaterials.7.3 Nanostructured biomimetic, bioresponsive and bioactive biomaterials.7.4 Conclusions.7.5 Exercises/Questions Chapter 7.7.6 References.