Behavioral Genetics of the Mouse

Susanna Pietropaolo is a Researcher at the Centre National de la Recherche Scientifique (CNRS). She is an expert in the behavioral analysis of the laboratory mouse, with a special interest in social behaviors. Her recent research focuses on mouse models of social dysfunction, including autism and Fragile X syndrome. Frans Sluyter is an expert in (wild) house mouse behavior and neurogenetics. His interests range from aggression, addiction, depression and (stress) coping strategies to gene expression profiles and consciousness. He has worked in The Netherlands, France, Japan and England. Wim E. Crusio is a Research Director at the Centre National de la Recherche Scientifique (CNRS). With over 35 years' experience in mouse behavioral neurogenetics and the analysis of mouse behavior, his recent interests cover mouse models of depression, autism, and Fragile X syndrome.

A comprehensive and critical overview of the major genetically modified mouse lines used to model human neurobehavioral disorders.

List of contributors; Part I. Introduction to Genetic Mouse Models of Neurobehavioral Disorders: 1. Introduction Frans Sluyter and Wim E. Crusio; 2. Developing mouse models of neurobehavioral disorders: when is a model a good model? F. Josef van der Staay, Saskia Arndt and Rebecca E. Nordquist; Part II. Perception Disorders: 3. Pain disorders Odd-Geir Berge; 4. Disorders of the visual system Stewart Thompson and Alisdair R. Philp; Part III. Autonomous and Motor Disorders: 5. Obesity and anorexia Gertjan van Dijk and Martien J. H. Kas; 6. Sleep disorders Glenda Lassi and Valter Tucci; 7. Cerebellar disorders Robert Lalonde and Catherine Strazielle; 8. Motor disorders David Gordon and Kevin Talbot; 9. Epilepsy Ortrud K. Steinlein; Part IV. Social Dysfunction and Mental Retardation: 10. Pathological aggression Frans Sluyter, Aki Takahashi and Stephen C. Maxson; 11. Disorders of sex Ashlyn Swift-Gallant and Douglas Ashley Monks; 12. Autism Valerie J. Bolivar; 13. Rett syndrome Laura Ricceri, Bianca De Filippis and Giovanni Laviola; 14. Fragile X syndrome Susanna Pietropaolo and E. Subashi; 15. Attention-deficit hyperactivity disorder Tatyana D. Sotnikova and Raul R. Gainetdinov; 16. Obsessive-compulsive disorder and Gilles de la Tourette's syndrome Nancy S. Woehrle and Stephanie C. Dulawa; 17. Schizophrenia Sofya Abazyan and Mikhail V. Pletnikov; 18. Down syndrome Mara Dierssen; 19. Prader-Willi and Angelmann syndromes Emily Y. Smith and James L. Resnick; 20. Williams syndrome Lucy R. Osborne and Zhengping Jia; Part V. Anxiety and Mood Disorders: 21. Anxiety disorders Guy Griebel and Sandra Beeské; 22. Depression Christopher R. Pryce and Federica Klaus; 23. Bipolar disorder Nirit Kara and Haim Einat; Part VI. Substance Dependence and Abuse: 24. Alcohol use disorders John C. Crabbe; 25. Drug abuse: nicotine Rebecca C. Steiner and Marina R. Picciotto; 26. Cannabis abuse and dependence Tim Karl and Jonathon C. Arnold; 27. Drug abuse: amphetamines Tamara J. Phillips, Emily C. Eastwood and John H. Harkness; 28. Cocaine-related disorders F. Scott Hall and Ichiro Sora; 29. Opioids-related disorders Angelo Contarino; Part VII. Neurodegenerative Disorders: 30. Alzheimer's disease Christopher Janus and David Borchelt; 31. Parkinson's disease Iddo Magen and Marie-Françoise Chesselet; 32. Huntington's disease Yoon H. Cho and Susanna Pietropaolo; Index.