Directed Drug Delivery

This book is based on the proceedings of the symposium entitled "Di rected Drug Delivery: A Multidisciplinary Problem," which was held in Lawrence, Kansas on October 17-19, 1984. The purpose of the sym posium and this book is to focus on the multidisciplinary nature of drug delivery. Development of a successful drug delivery system re quires contributions from various scientific disciplines, including pharmaceutical chemistry, analytical chemistry, medicinal chemistry, biochemistry, pharmacology, toxicology, and clinical medicine. The contents of this volume illustrate the importance of the various disci plines in identifying the problems and approaches for the develop ment of a rational and effective drug delivery system. Thus the infor mation provided herein will be of value not only to the pharmaceutical chemists who are responsible for dosage form design, but also to the pharmacokineticists, pharmacologists, and clinicians involved in bio logical evaluation of drug delivery systems. The volume should also be of interest to the analytical chemists who must provide technology to quantitcltively evaluate drug delivery. Additionally, this work will also interest the biochemists and medicinal chemists involved in drug dis covery, since the drug delivery system often plays a major role in determining the success or failure of a new drug entity. Each speaker at the symposium was requested to contribute a chapter reviewing the contribution of their major discipline to the de velopment of a successful drug delivery system.

A. Pharmacodynamic and Pharmacokinetic Factors Influencing Directed Drug Delivery.- Pharmaceutics and the Evolving Technology of Drug Delivery-A Perspective.- Pharmacodynamic Considerations in the Development of New Drug Delivery Concepts.- Molecular Mechanisms of Drug Action and Pharmacokinetic-Pharmacodynamic Models.- The Therapeutic System: Therapeutic Implications of Rate-Controlled Drug Delivery.- B. Physiological and Biochemical Factors Influencing Directed Drug Delivery.- Gastrointestinal Barrier to Oral Drug Delivery.- Strategies for Drug Delivery Through the Blood-Brain Barrier.- The Dermal Barrier to Local and Systemic Drug Delivery.- C. Physical-Chemical Approaches to Directed Drug Delivery.- A Physical Approach to Drug Delivery.- Microparticulate Drug Carriers.- Biodegradable Poly(ortho Esters) as Drug Delivery Forms.- Macromolecules as Drug Delivery Systems.- D. Biological-Chemical Approaches to Directed Drug Delivery.- Monoclonal Antibody Mediated Drug Delivery and Antibody Toxin Conjugates.- Drug Delivery Via Cell-Surface Receptors.- Prodrugs: A Chemical Approach to Targeted Drug Delivery.- New Drug Delivery Systems: Physico-Chemical Considerations.- E. Analytical Aspects of Drug Delivery.- Analytical Aspects of Drug Delivery: An Important and Often Overlooked Problem.- Applications of Miniature Electrodes to Biomedical Studies.- The Use of Scintigraphic Methods for the Evaluation of Novel Delivery Systems.- Approaches to Improve Specificity and Sensitivity in Chromatography.