Deconstructing Psychosis

For the many psychiatrists, psychologists, and other clinicians and researchers striving to bring symptom relief to patients with schizophrenia, bipolar disorder, and other psychoses, this volume provides an all-important summary of the latest research about the diagnosis and pathophysiology of psychosis.

Deconstructing Psychosis: Refining the Research Agenda for DSM-V provides an all-important summary of the latest research about the diagnosis and pathophysiology of psychosis. This volume gives the reader an inside look at how psychotic phenomena are represented in the current diagnostic system and how DSM-V might better address the needs of patients with such disorders.

The book presents a selection of papers reporting the proceedings of a conference titled "Deconstructing Psychosis" convened by the American Psychiatric Association (APA) in collaboration with the World Health Organization (WHO) and the U.S. National Institutes of Health (NIH). The conference was designed to be a key element in the multiphase research review process for the fifth revision of DSM. This book is one in a series of ten that reflects some of the most current and critical examinations of psychiatric disorders and psychotic syndromes. APA published the fourth edition of DSM in 1994 and a text revision in 2000. DSM-V is scheduled for publication in 2013.

Deconstructing Psychosis: Refining the Research Agenda for DSM-V examines the current evidence regarding the diagnosis and pathophysiology of common psychotic syndromes including: • Schizophrenia• Bipolar disorder• Major depressive psychosis• Substance-induced psychosis

It also addresses broad issues relating to diagnosis such as the ways in which psychosis cuts across multiple diagnostic categories. Beyond merely summarizing the current state of the science, the authors of these papers critique the current research and clinical evidence, and raise questions about gaps in our knowledge.

The book provides recommendations for the most promising areas of research in psychosis, which may lead to more refined treatments based on a better understanding of what biological and environmental factors contribute to its development and symptoms.

In the learned editors' selection of papers for inclusion in this volume, they have exhibited their conviction that DSM-V is a "living document" that will reflect the pace of progress in multiple areas, ranging from molecular genetics and brain imaging to social, behavioral, and anthropological science.

As a book on the narrowly defined topic of linking the classification of psychotic syndromes with their underlying pathophysiology and potential etiology, there is no other writing of comparable content available today.

CONTRIBUTORSDISCLOSURE STATEMENTFOREWORD: Rethinking Psychosis in DSM-VINTRODUCTIONChapter 1. DECONSTRUCTING PSYCHOSIS CONFERENCE FEBRUARY 2006: The Validity of Schizophrenia and Alternative Approaches to the Classification of PsychosisChapter 2. BIOLOGICAL, LIFE COURSE, AND CROSS-CULTURAL STUDIES ALL POINT TOWARD THE VALUE OF DIMENSIONAL AND DEVELOPMENTAL RATINGS IN THE CLASSIFICATION OF PSYCHOSISChapter 3. CURRENT ISSUES IN THE CLASSIFICATION OF PSYCHOTIC MAJOR DEPRESSIONChapter 4. DECONSTRUCTING BIPOLAR DISORDER: A Critical Review of Its Diagnostic Validity and a Proposal for DSM-V and ICD-1Chapter 5. DSM-V RESEARCH AGENDA: Substance Abuse/Psychosis ComorbidityChapter 6. THE GENETIC DECONSTRUCTION OF PSYCHOSISChapter 7. HOW SHOULD DSM-V CRITERIA FOR SCHIZOPHRENIA INCLUDE COGNITIVE IMPAIRMENT?Chapter 8. SEARCHING FOR UNIQUE ENDOPHENOTYPES FOR SCHIZOPHRENIA AND BIPOLAR DISORDER WITHIN NEURAL CIRCUITS AND THEIR MOLECULAR REGULATORY MECHANISMSChapter 9. DECONSTRUCTING PSYCHOSIS WITH HUMAN BRAIN IMAGINGChapter 10. IDENTIFYING FUNCTIONAL NEUROIMAGING BIOMARKERS OF BIPOLAR DISORDER: Toward DSM-VChapter 11. THE NEUROPHARMACOLOGY OF PSYCHOSISINDEX