Generation and Interpretation of Morphogen Gradients

Signaling by diffusible morphogens, such as Hedgehog, Wingless, TGF-, and various growth factors, is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues. The expert contributors to this volume discuss the roles of morphogen gradients in organisms from yeast to humans. They examine the regulation of morphogen synthesis, trafficking, and diffusion, as well as the complex webs of signaling mechanisms and transcriptional responses in recipient cells. The book is a vital reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis.

Robust Generation and Decoding of Morphogen Gradients Naama Barkai and Ben-Zion Shilo Nodal Morphogens Alexander F. Schier Forming Patterns in Development Without Morphogen Gradients: Scattered Differentiation and Sorting Out Robert R. Kay and Christopher R.L. Thompson Graded Dorsal and Differential Gene Regulation in the Drosophila Embryo Gregory T. Reeves and Angelike Stathopoulos Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning: The Role of Negative Feedback V. Ribes and J. Briscoe Signaling Gradients During Paraxial Mesoderm Development Alexander Aulehla and Olivier Pourqui e9; Gradients in the Brain: The Control of the Development of Form and Function in the Cerebral Cortex Stephen N. Sansom and Frederick J. Livesey Morphogen Gradient Formation Marcos Gonz e1;lez-Gait e1;n, Anna Kicheva, and Ortrud Wartlick Shaping Morphogen Gradients by Proteoglycans Dong Yan and Xinhua Lin Vertebrate Limb Development: Moving From Classical Morphogen Gradients to an Integrated 4D Patterning System Jean-Denis B e9;nazet and Rolf Zeller The Measure of Success: Constraints, Objectives, and Tradeoffs in Morphogen-Mediated Patterning Arthur D. Lander, Wing-Cheong Lo, Qing Nie and Frederic Y.M.Wan Regulation of Organ Growth by Morphogen Gradients Gerald Schwank and Konrad Basler Forming and Interpreting Gradients on the Early Xenopus Embryo J.C. Smith Gradients in Planarian Regeneration and Homeostasis T. Adell, F. Cebri e0; And E. Sal f3; Gradients and the Specification of Planar Polarity in the Insect Cuticle David Strutt Systems Biology of the Self-Regulating Morphogenetic Gradient of the Xenopus Gastrula Jean-Louis Plouhinec and E.M. De Robertis Axial Patterning in Hydra Hans R. Bode Chemical Gradients and Chemotropism in Yeast Robert A. Arkowitz Models for the Generation and Interpretation of Gradients Hans Meinhardt Index