Annual Review of Gerontology and Geriatrics, Volume 34, 2014

Enormous advances in our knowledge of genetic contributions to aging and disease, and in our understanding of the potential for manipulation of the aging process, have taken place during the past 20 years. This is the first volume in decades to consolidate this research in one place. It provides a broad and current overview of the most promising advances in genetic research on aging, current understanding of genetic contributions to the basic processes of aging, and age-related disease. The Review focuses on the aging process from lower organisms to man, and is organized in ascending order of biological complexity starting with stem cells and progressing through worms, flies, mice, and humans. Where relevant, the Review also includes information about yeasts and non-human primates.

The research presented in the Review uses a species-comparative approach that makes finding cross species similarities (gene conservation) and differences (gene differentiation) apparent. This approach reflects the way in which the field is organized, making it highly useful for investigators who want quick access and a concise summary of a particular topic.

Key Features:

• Provides state-of-the-art information about promising advances in genetic research on aging
• Comprises the first comprehensive volume regarding genetic research about aging in decades
• Authored by leading scholars in the field
• Disseminates enormous advances in our understanding of the aging process

Preface

1. Longevity pathways in mammalian stem cells

Anne Brunet, Salah Mahmoudi, Elena Mancini, Victoria A. Rafalski, and Ashley E. Webb

2. Essential Genes and Lifespan

Sean P. Curran

3. Oxygen and Aging

Jason N. Pitt, Scott F. Leiser, and M. Kaeberlein

4. Aging, Disease and Longevity in Mice

David B. Lombard and Richard A. Miller

5. Primate Models for Human Brain Aging and Neurological Diseases

Caleb Finch and Steve Austad

6. Genes for Exceptional Longevity

Nir Barzilai and Gil Atzmon

7. Etiology of Individual Differences in Human Health and Longevity

Deborah Finkel, Lotte Gerritsen, Chandra A. Reynolds, Anna K. Dahl, and Nancy L. Pedersen

8 Exploiting causal complexity in aging

Gerald E. McClearn, David J. Vandenbergh, J. Tobias Stout, and Roger J. McCarter

9. Networks in the Biology of Aging: Powerful tools for a complex process

Mark A. McCormick and Daniel E. L. Promislow

10. Nature, Nurture & Chance: Their Roles in Interspecific & Intraspecific Modulations of Aging

George M. Martin