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Comparative Pharmacokinetics
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Principles, Techniques and Applications
Besorgungstitel - wird vorgemerkt | Lieferzeit: Besorgungstitel - Lieferbar innerhalb von 10 Werktagen I
Artikel-Nr:
9780813829937
Veröffentl:
2011
Erscheinungsdatum:
12.04.2011
Seiten:
376
Autor:
Jim E Riviere
Gewicht:
1026 g
Format:
261x182x28 mm
Sprache:
Englisch
Beschreibung:
Jim Riviere, DVM, PhD, DSc (hon), ATS, is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology, Alumni Distinguished Graduate Professor, and Director of the Center for Chemical Toxicology Research and Pharmacokinetics at North Carolina State University, and Editor of the Journal of Veterinary Pharmacology and Therapeutics.
Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Designed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics. Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Designed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.
The second edition retains the structure of the first, beginning with the basic principles of physiology and then moving into the primary approaches used in pharmacokinetic modeling, including extensive coverage of dosage regimens and adjustments, interspecies extrapolation, experimental design, data collection and analysis, and residues and withdrawal times. With broad human and animal species coverage, Comparative Pharmacokinetics is essential reading for those working in drug research and development, as well as those with advanced interest in pharmacology and toxicology in veterinary or comparative medicine.
Key features
Provides a detailed but understandable reference on the conceptual basis of veterinary and comparative pharmacokinetics
Covers practical applications to both animal and human medicine
Offers essential information for ensuring that pharmacokinetics studies are correctly designed and interpreted
Includes new chapters on quantitative structure permeability relationships and bioequivalence, as well as fully revised and expanded chapters throughout
Presents a fully rewritten chapter on simultaneous pharmacokinetic-pharmacodynamic modeling to reflect its newly widespread role in comparative medicine
Facilitates the reader in making conceptual linkages between theory and applications with expanded cross-referencing between topics
The second edition retains the structure of the first, beginning with the basic principles of physiology and then moving into the primary approaches used in pharmacokinetic modeling, including extensive coverage of dosage regimens and adjustments, interspecies extrapolation, experimental design, data collection and analysis, and residues and withdrawal times. With broad human and animal species coverage, Comparative Pharmacokinetics is essential reading for those working in drug research and development, as well as those with advanced interest in pharmacology and toxicology in veterinary or comparative medicine.
Key features
Provides a detailed but understandable reference on the conceptual basis of veterinary and comparative pharmacokinetics
Covers practical applications to both animal and human medicine
Offers essential information for ensuring that pharmacokinetics studies are correctly designed and interpreted
Includes new chapters on quantitative structure permeability relationships and bioequivalence, as well as fully revised and expanded chapters throughout
Presents a fully rewritten chapter on simultaneous pharmacokinetic-pharmacodynamic modeling to reflect its newly widespread role in comparative medicine
Facilitates the reader in making conceptual linkages between theory and applications with expanded cross-referencing between topics
Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner.
Preface.
Chapter 1: Introduction.
Chapter 2: Principles of Drug Movement in the Body.
Chapter 3: Quantitative Structure Permeability Relationships (QSPeR).
Chapter 4: Absorption.
Chapter 5: Distribution.
Chapter 6: Renal Elimination.
Chapter 7: Hepatic Biotransformation and Biliary Excretion.
Chapter 8: Compartmental Models.
Chapter 9: Noncompartmental Models.
Chapter 10: Nonlinear Models.
Chapter 11: Physiological Models.
Chapter 12: Dosage Regimens.
Chapter 13: Simultaneous Pharmacokinetic-Pharmacodynamic Modeling.
Chapter 14: Study Design and Data Analysis.
Chapter 15: Design and Analysis of Bioequivalence Studies and FDA's in vitro/in vivo (IVIV).
Chapter 16: Population Pharmacokinetic Models and the Bayesian Forecasting Applied to Clincal Pharmacokinetics.
Chapter 17: Dosage Adjustments in Renal (and Hepatic) Disease.
Chapter 18: Interspecies Extrapolations.
Chapter 19: Tissue Residues and Withdrawal TimesAppendix
Chapter 1: Introduction.
Chapter 2: Principles of Drug Movement in the Body.
Chapter 3: Quantitative Structure Permeability Relationships (QSPeR).
Chapter 4: Absorption.
Chapter 5: Distribution.
Chapter 6: Renal Elimination.
Chapter 7: Hepatic Biotransformation and Biliary Excretion.
Chapter 8: Compartmental Models.
Chapter 9: Noncompartmental Models.
Chapter 10: Nonlinear Models.
Chapter 11: Physiological Models.
Chapter 12: Dosage Regimens.
Chapter 13: Simultaneous Pharmacokinetic-Pharmacodynamic Modeling.
Chapter 14: Study Design and Data Analysis.
Chapter 15: Design and Analysis of Bioequivalence Studies and FDA's in vitro/in vivo (IVIV).
Chapter 16: Population Pharmacokinetic Models and the Bayesian Forecasting Applied to Clincal Pharmacokinetics.
Chapter 17: Dosage Adjustments in Renal (and Hepatic) Disease.
Chapter 18: Interspecies Extrapolations.
Chapter 19: Tissue Residues and Withdrawal TimesAppendix
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