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Hemopoietic Colony-Stimulating Factors
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From Biology to Clinical Applications
HC gerader Rücken kaschiert
Print on Demand | Lieferzeit: Print on Demand - Lieferbar innerhalb von 3-5 Werktagen I
Artikel-Nr:
9780521461580
Veröffentl:
2014
Einband:
HC gerader Rücken kaschiert
Erscheinungsdatum:
13.08.2014
Seiten:
354
Autor:
Donald Metcalf
Gewicht:
666 g
Format:
235x157x24 mm
Sprache:
Englisch
Beschreibung:
This book provides a detailed and up-to-date account of the discovery of the CSFs, their structure, molecular biology, and cellular receptors, the biology of the CSFs in vivo and in vitro, and their present and possible future clinical applications. Written by two of the pioneers in the discovery of the CSFs, it is a clear and well-illustrated survey of the history, current knowledge, and future directions of this exciting field of investigation, and also serves as a guide to the more general areas of growth factor and cytokine research. It will prove an invaluable review for cell biologists interested in how growth factors act on the body, as well as for clinicians applying the fruits of modern biotechnology to improved patient care.
Preface; 1. Historical introduction; 2. General introduction to hemopoiesis; 3. Key techniques in analyzing hemopoiesis; 4. Biochemistry of the colony-stimulating factors; 5. Biochemistry of the colony-stimulating factor receptors; 6. Molecular genetics of the colony-stimulating factors and their receptors; 7. Biological actions of the colony-stimulating factors in vitro; 8. The biology of colony-stimulating factor production, degradation and clearance; 9. Actions of the colony-stimulating factors in vivo; 10. Role of the colony-stimulating factors in basal hemopoiesis; 11. Actions of the colony-stimulating factors in resistance to infections; 12. Role of the colony-stimulating factors in other disease states; 13. The colony-stimulating factors and myeloid leukemia; 14. Clinical uses of the colony-stimulating factors; 15. Conclusions; References; Index.