Drug Discovery Handbook

The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

The Drug Discovery Handbook gives professionals a tool tofacilitate drug discovery by bringing together, for the first timein one resource, a compendium of methods and techniques that needto be considered when developing new drugs.This comprehensive, practical guide presents an explanation of thelatest techniques and methods in drug discovery, including:* Genomics, proteomics, high-throughput screening, and systemsbiology* Summaries of how these techniques and methods are used todiscover new central nervous system agents, antiviral agents,respiratory drugs, oncology drugs, and more* Specific approaches to drug discovery, including problems thatare encountered, solutions to these problems, and limitations ofvarious methods and techniquesThe thorough coverage and practical, scientifically validproblem-solving approach of Drug Discovery Handbook will serve asan invaluable aid in the complex task of developing new drugs.

Preface.Introduction: Drug Discovery in the 21st Century.1. Natural Products (Charles B. Spainhour).2. Cancer Cell Proteomics Using Molecular Aptamers (Weihong Tan,Zehui Cao, Dihua Shangguan, Ying Li, Zhiwen Tang, PrabodhikaMallikratchy, and Hui Chen).3. Molecular Similarity Methods and QSAR Models as Tools forVirtual Screening (Jürgen Bajorath).4. Systems Biology: Applications in Drug Discovery (Sean Ekins,Andrej Bugrim, Yuri Nikolsky, and Tatiana Nikolskaya).5. High-Throughput Flow Cytometry (Larry A. Sklar, Peter C.Simons, Anna Waller, Sean M. Biggs, Susan M. Young, Marius Olah,Cristian Bologa, Tudor I. Oprea, Eric R. Prossnitz, and Bruce S.Edwards).6. Combining NMR Spectral Information with Associated StructuralFeatures to Form Computationally Nonintensive, Rugged, andObjective Models of Biological Activity (Richard D. Beger, Dan A.Buzatu, and Jon G.Wilkes).7. Using Microsoft Excel® as a Laboratory Data ManagementTool (A. Erik Rubin, Mark F. Russo, and William Neil).8. Age of Regulation (Sandy Weinberg and Gerald J.Whartenby).9. Simultaneous Screening of Multiple Cell Lines Using theCellCard System (Oren E. Beske).10. Protein X-ray Crystallography in Drug Discovery (PeterNollert, Michael D. Feese, Bart L. Staker, and Hidong Kim).11. Biological and Chemistry Assays Available During DrugDiscovery and Developability Assessment (Duane B. Lakings).12. Strategies and Methods in Monitoring and TargetingProtein-Protein Interactions (Arianna Loregian and GiorgioPalù)13. High-Throughput Screening: Evolution of Technology andMethods (Martyn N. Banks, Angela M. Cacace, JonathanO'Connell, and John G. Houston).14. Metal-Enhanced Fluorescence: Application to High-ThroughputScreening and Drug Discovery (Kadir Aslan, Ignacy Gryczynski,Joanna Malicka, Joseph R. Lakowicz, and Chris D. Geddes).15. Methods for the Design and Analysis of Replicate-ExperimentStudies to Establish Assay Reproducibility and the Equivalence ofTwo Potency Assays (Brian J. Eastwood, Amy K. Chesterfield, MaryC.Wolff, and Christian C. Felder).16. Coupled Luminescent Methods in Drug Discovery: 3-Min Assaysfor Cytotoxicity and Phosphatase Activity (Michael J. Corey andRobert J. Kinders).17. Design and Pharmaceutical Applications of Prodrugs (TomiJärvinen, Jarkko Rautio, Mar Masson, and ThorsteinnLoftsson).18. GABA and Glutamate Receptor Ligands and Their TherapeuticPotential in CNS Disorders (Ulf Madsen, Hans Bräuner-Osborne,Jeremy R. Greenwood, Tommy N. Johansen, Povl Krogsgaard-Larsen,Tommy Liljefors, Mogens Nielsen, and Bente Frølund).19. Cardiac Sarcolemmal ATP-Sensitive Potassium ChannelAntagonists: Novel Ischemia-Selective Antiarrhythmic Agents (GeorgeE. Billman).20. Factors Influencing the Efficacy of Mediator-SpecificAnti-Inflammatory, Glucocorticoid, and Anticoagulant Therapies forSepsis (Peter C. Minneci, Katherine J. Deans, Michael Haley,Xizhong Cui, Charles Natanson, and Peter Q. Eichacker).21. Combinatorial Chemistry in the Drug Discovery Process(Nathan T. Ross, Brian R. McNaughton, and Benjamin L. Miller).22. Herbal Medicines and Animal Models of GastrointestinalDiseases (C.H. Cho and J.K.S. Ko).23. Endocrine and Metabolic Agents (Brian L. Furman).24. Respiratory Viruses (Paul D. Olivo).25. Strategies in the Design of Antiviral Drugs (Erik De Clercqand Piet Herdewijn).26. Protein Kinase Inhibitors in Drug Discovery (KeykavousParang and Gongqin Sun).27. RNA-Based Therapies (Steve Pascolo).28. Novel Imaging Agents for Molecular MR Imaging of Cancer(Dmitri Artemov and Zaver M. Bhujwalla).29. Targets and Approches for Cancer Drug Discovery (Susan L.Mooberry).Index.