Bioinformatics and Functional Genomics

Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "e;Teacher of the Year"e; award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.

Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.

PART I: ANALYZING DNA, RNA, AND PROTEIN SEQUENCES IN DATABASES.1. Introduction.2. Access to Sequence Data and Literature Information.3. Pairwise Sequence Alignment.4. Basic Local Alignmnet Search Tool (BLAST).5. Advanced BLAST Searching.PART II: GENOMEWIDE ANALYSIS OF RNA AND PROTEIN.6. Bioinformatic Approaches to Gene Expression.7. Gene Expression: Microarrays Data Analysis.8. Protein Analysis and Proteomics.9. Protein Structure.10. Multiple Sequence Alignment.11. Molecular Phylogeny and Evolution.PART III: GENOME ANALYSIS.12. Completed Genomes and the Tree of Life.13. Completed Genomes: Viruses.14. Completed Genomes: Bacteria and Archaea.15. Eukaryotic Genomes: Fungi16. Eukaryotic Genomes: From Parasites to Primates.17. The Human Genome.18. Human Disease.Epilogue.Appendix: GCG for Protein and DNA Analysis.Glossary.Solutions to Self-Test Quizzes.Subject Index.Author Index.