Systems Biology and Livestock Science

Systems Biology is an interdisciplinary approach to the study of life made possible through the explosion of molecular data made available through the genome revolution and the simultaneous development of computational technologies that allow us to interpret these large data sets. Systems Biology has changed the way biological science views and studies life and has been implemented in research efforts across the biological sciences. Systems Biology and Livestock Science will be the first book to review the latest advances using this research methodology in efforts to improve the efficiency, health, and quality of livestock production. Systems Biology and Livestock Science opens with useful introductory chapters explaining key systems biology principles. The chapters then progress to look at specific advances in fields across livestock science. Coverage includes, but is not limited to, chapters on systems biology approaches to animal nutrition, reproduction, health and disease, and animal physiology. Written by leading researchers in the field, Systems Biology and Livestock Science, will be an invaluable resource to researchers, professionals, and advance students working in this rapidly developing discipline.

Systems Biology is an interdisciplinary approach to the study of life made possible through the explosion of molecular data made available through the genome revolution and the simultaneous development of computational technologies that allow us to interpret these large data sets. Systems Biology has changed the way biological science views and studies life and has been implemented in research efforts across the biological sciences. Systems Biology and Livestock Science will be the first book to review the latest advances using this research methodology in efforts to improve the efficiency, health, and quality of livestock production.Systems Biology and Livestock Science opens with useful introductory chapters explaining key systems biology principles. The chapters then progress to look at specific advances in fields across livestock science. Coverage includes, but is not limited to, chapters on systems biology approaches to animal nutrition, reproduction, health and disease, and animal physiology.Written by leading researchers in the field, Systems Biology and Livestock Science, will be an invaluable resource to researchers, professionals, and advance students working in this rapidly developing discipline.

List of Contributors viiPreface xiChapter 1. Introduction to Systems Biology for Animal Scientists 1Christopher K. Tuggle, Fadi Towfic, and Vasant G. HonavarChapter 2. Modeling Approaches in Systems Biology, Including Silicon Cell Models 31Alexey N. Kolodkin, Fred C. Boogerd, Frank J. Bruggeman, and Hans V. WesterhoffChapter 3. The IUPS Physiome Project: A Worldwide Systems Biology Initiative 53Gregory O'Grady, Peng Du, and Leo K. ChengChapter 4. Systems Biology in Livestock Health and Disease 83Gordon M. KirbyChapter 5. Systems Biology of Host-Food-Microbe Interactions in the Mammalian Gut 109Vitor A.P. Martins dos Santos, Michael Muller, Willem M. de Vos, Jerry Wells, Marinus F.W. te Pas, Guido Hooiveld, Peter van Baarlen, Mari A. Smits, and Jaap KeijerChapter 6. From Visual Biological Models Toward Mathematical Models of the Biology of Complex Traits 137Marinus F.W. te Pas, Arend J.W. Hoekman, and Ina HulseggeChapter 7. Molecular Networks as Sensors and Drivers of Uterine Receptivity in Livestock 161Stefan Bauersachs and Eckhard WolfChapter 8. Modeling Approaches to Link Various Levels of Organization in Animal Physiology 191Andre Bannink, James France, and Jan DijkstraChapter 9. Systems Biology and Animal Nutrition: Insights from the Dairy Cow During Growth and the Lactation Cycle 215Juan J. Loor, Massimo Bionaz, and Guido InvernizziChapter 10. Host-Pathogen Interactions 247Mari A. Smits and Dirkjan SchokkerChapter 11. Systems Biology in Livestock Science and Commercial Livestock Business 277Marinus F.W. te Pas, Henri Woelders, and Andre BanninkIndex 287