Fundamental Neuropathology for Pathologists and Toxicologists

This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

This book offers pathologists, toxicologists, other medicalprofessionals, and students an introduction to the discipline andtechniques of neuropathology - including chemical andenvironmental, biological, medical, and regulatory detailsimportant for performing an analysis of toxicant-inducedneurodiseases. In addition to a section on fundamentals, the bookprovides detailed coverage of current practices (bioassaysmolecular analysis, and nervous system pathology) and practicalaspects (data interpretation, regulatory considerations, and tipsfor preparing reports).

Editors' Preface.Forward.Acknowledgments.Part I. Fundamentals of Neurobiology.Chapter 1. Fundamentals of Toxicologic Neuropathology: AnIntroduction.Chapter 2. Functional Neuroanatomy.Chapter 3. Atlas of Comparative Neuroanatomy.Chapter 4. Principles of Comparative and CorrelativeNeurodevelopment, and their Implications for DevelopmentalNeurotoxicity.Chapter 5. Localizing Neuropathologic Lesions Using NeurologicFindings.Chapter 6. Behavioral Model Systems for EvaluatingNeuropathology.Chapter 7. Cognitive Assessments in Non-Human Primates.Chapter 8. The Impact of Aging on Brain Structure and Functionin Rodents and Canines.Chapter 9. Fundamentals of Neurotoxicity Detection.Part 2. Toxicologic Neuropathology: Methodology.Chapter 10. Practical Neuropathology of the Rat and OtherSpecies.Chapter 11. The Fluoro-Jade Dyes: Novel, Sensitive, and ReliableFluorochromes for the Histochemical Localization of DegeneratingNeurons.Chapter 12. Histologic Markers of Neurotoxicity(Nonfluorenscence).Chapter 13. Common Histologic Artifacts in Nervous SystemTissues.Chapter 14. High-Definition Microscopic Analysis of the NervousSystem.Chapter 15. Stereological Solutions for Common QuantitativeEndpoints in Neurotoxicity.Chapter 16. Anatomy and Processing of Peripheral NerveTissues.Chapter 17. Pathology Methods in Non-clinical NeurotoxicityStudies: Evaluation of Muscle.Chapter 18. In Vivo Imaging Applications for the NervousSystem in Animal Models.Chapter 19. Cerebrospinal Fluid Analysis in ToxicologicNeuropathology.Chapter 20. Molecular Techniques in ToxicologicNeuropathology.Part 3. Toxicologic Neuropathology: Current Practices.Chapter 21. Evaluation of the Adult Nervous System inPreclinical Studies.Chapter 22. Pathology Methods in Non-clinical NeurotoxicityStudies: Developing Central Nervous System.Chapter 23. Neuropathology Analysis of the Peripheral NervousSystem.Chapter 24. Toxicologic Pathology of the Retina and OpticNerve.Chapter 25. Toxicologic Neurpathology of the Ear.Chapter 26. Neurpathology of the Olfactory System.Part 4. Applied Toxicologic Neuropathology.Chapter 27. Spinal Delivery and Assessment of Drug Safety.Chapter 28. Diagnostic Neuropathology.Chapter 29. Toxicologic Neuropathology in Medical Practice.Chapter 30. Toxiciologic Neuropathology in VeterinaryPractice.Chapter 31. Regulatory Considerations in ToxicologicNeuropathology.Chapter 32. The Neuropathology Report and the NeuropathologyPeer Review Report.Chapter 33. Preparation of Personnel for NeuropathologyAssessment.Chapter 34. Regulatory Guide to the Histopathologic Assessmentof Neurotoxicity Studies.Chapter 35. Toxicologic Neuropathology: The Next TwoDecades.Appendices.Ready References of Neurobiology Knowledge.Appendix 1. Neural Cell Markers of Potential Utility forToxicologic Neuropathology Applications.Appendix 2. Neuroanatomic Atlases for Toxicologic NeuropathologyStudies.Appendix 3. Text-Based Basic Neurobiology References forToxicologic Neuropathologists.Appendix 4. Web-Based Neurobiology References for ToxicologicNeuropathogists.Appendix 5. Toxicologic Neuropathology References for NervousSystem Targets.Appendix 6. Comparative and Correlative NeurobiologicalParameters Related to Neuropathology Assessment.Appendix 7. Comparison of Central Nervous System ProportionsBetween Humans and Rats.Appendix 8. Chemical Composition of Central Nervous SystemTissues and Fluids.