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RNA Interference
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Application to Drug Discovery and Challenges to Pharmaceutical Development
E-Book
Sofort lieferbar | Lieferzeit: Sofort lieferbar
Artikel-Nr:
9780470934678
Veröffentl:
2011
Einband:
E-Book
Seiten:
336
Autor:
Paul H. Johnson
eBook Typ:
EPUB
eBook Format:
Reflowable E-Book
Kopierschutz:
Adobe DRM [Hard-DRM]
Sprache:
Englisch
Beschreibung:
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
CONTRIBUTORS.PREFACE.FOREWORD.I. Biology of RNA Interference.1 RNA Interference: What is it? (James A. Birchler).2 Nucleic Acids as Regulatory Molecules (Faqing Huang, C. J.Yu, and Yanlin Guo).3 Use of siRNA Oligonucleotides to Study Gene Function(Kristin A. Wiederholt and Adam N. Harris).4 Genome Scanning by RNA Interference (Roderick L.Beijersbergen and Oliver C. Steinbach).II Development of siRNA for Therapeutic Applications.5 Discovery of New siRNA Delivery Agents (Paul H. JohnsonDiane Frank, Kunyuan Cui, Roger Adami, Harry Wang, Michael Houstonand Steven C. Quay).6 siRNA Delivery Vehicles (Aliasger K. Salem and Mark A.Behlke).7 Interferon, Cytokine Induction and Other Potential InVivo Toxicities (Adam Judge, Marjorie Robbins, and IanMacLachlan).8 Application of RNA Interference to Viral Diseases (Ralph A.Tripp and Stephen Mark Tompkins).Index.