Biomarkers

This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.

This book provides an introduction to the field of biomarkers, howthey have been and can be used, and how different approaches can beused to identify, characterize, and monitor biomarkers. The bookhas chapters on topics including HIV, Cancer, Parkinson'svascular injury, environmental exposure. A following sectiondiscusses the technologies (diagnostics and assays) to detectbiomarkers and authors have emphasized the preclinical and clinicalmanifestation of the injury/disease process.

Preface xxiiContributors xxv1 Biomarkers: An Evolutionary Perspective 1Michael Ferguson and Vishal VaidyaSection I: Tools for Biomarker Discovery 52 Genomics 7Weida Tong and Donna L. Mendrick3 Proteomics for Biomarker Discovery 25Timothy D. Veenstra4 Metabolic Profiling for Biomarker Discovery 47Hector C. Keun5 The Bittersweet Promise of Glycobiology 75Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya SenguptaSection II: Biomarkers of Injury/Disease 896 Biomarkers of Alzheimer's and Parkinson's Disease 91Walter Maetzler and Daniela Berg7 Biomarkers of Cardiac Injury 119Anthony S. McLean and Stephen J. Huang8 Lung Injury Biomarkers 157Urmila P. Kodavanti9 Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities 203Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah10 Biomarkers of Acute Kidney Injury 237Frank Dieterle and Frank Sistare11 In Search of Biomarkers for Drug-Induced Vascular Injury 281James R. Turk12 Biomarkers of Immunotoxicity 307Rodney R. Dietert13 Biomarkers in Obstetric Medicine 323Manish Maski, Sarosh Rana and S. Ananth Karumanchi14 Biomarkers in Cancer 355Roopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses15 Biomarkers of HIV 381Lewis Kaufman and Michael J Ross16 Biomarkers of in Vitro Drug-Induced Mitochondrial Dysfunction 401James A. Dykens and Yvonne WillSection III: Technology for Biomarker Detection 42317 Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research 425Vincent Ricchiuti18 Nanoscale Techniques for Biomarker Quantification 457Madhukar Varshney, and Harold G. Craighead19 Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices 495Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. MefferdSection IV: Hot Topics In Biomarker Research 51720 Biomarkers for Environmental Exposure 519Jane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards21 Clinical Study Design in Biomarker Research 549Orfeas Liangos and Bertrand L. Jaber22 Statistical Issues in Biomarker Research 561Daniel Holder and Matthew Schipper23 Regulatory Perspective for Biomarker Qualification from U.S. FDA 581Federico Goodsaid24 The European Medicines Agency Approach 589Marisa Papaluca Amati and Spiros VamvakasIndex 595