Pharmaceutical Process Chemistry for Synthesis

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today the push for "e;greener"e; processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

There is a need to explain that generic versions of a drug maynot be manufactured by the same process as brand-name drugs andthat the different processes may have dramatically differentenvironmental impacts. Two global forces are at oddstoday--the push for "greener" processes and the push for lowerdrug prices. This book brings this conflict into sharp focus bydiscussing in detail the published process chemistry fortop-selling small molecule drugs.Providing insights about process route selection, choice ofreagents, and reaction conditions, Pharmaceutical ProcessChemistry for Synthesis guides process chemists in identifyingbest processes for manufacturing these blockbuster drugs as theylose patent protection. Further, it highlights the strategies andmethodology that might be useful for expediting the processresearch and development of the blockbusters of the future.Written from a refreshingly objective perspective, this book isessential for process chemists who need to devise practicalsyntheses for increasingly complex drugs in a constantly decreasingtime frame.

1 Introduction.2 Actos® (Pioglitazone Hydrochloride).3 Lexapro® (Escitalopram Oxalate).4 Efferox XR® (Venlafaxine Hydrochloride).5 Seroquel® (Quetiapine Hemifumarate).6 Singulair® (Montelukast Sodium).7 Prevacid® (Lansoprazole).8 Advair Diskus® (Salmeterol Xinafoate).9 Lipitor® (Aatorvastatin Calcium).Index.