Cardiovascular Genetics and Genomics for the Cardiologist

Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine. In this timely volume, Drs. Dzau and Liew both pioneers in the area help cardiologists understand: how cardiovascular genetics may remodel the way cardiovascular medicine is practiced what material has immediate relevance to the practicing clinician how to incorporate genetics and genomics in your practice to ensure up-to-date patient care The book opens with introductory chapters, then discusses: cardiovascular single gene disorders cardiovascular polygenic disorders therapies and applications Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.

Until recently, a modest knowledge of genetics was more thanadequate for the daily practice of clinical cardiology, butadvances in genetics and genomics are changing cardiovascularmedicine in fundamental ways. The identification of the geneticbasis of several forms of dyslipidemia, hypertension, diabetescardiomyopathies, and vascular diseases signalled the newimportance of genetics in clinical medicine.In this timely volume, Drs. Dzau and Liew - both pioneersin the area - help cardiologists understand:* how cardiovascular genetics may remodel the waycardiovascular medicine is practiced* what material has immediate relevance to the practicingclinician* how to incorporate genetics and genomics in your practiceto ensure up-to-date patient careThe book opens with introductory chapters, then discusses:* cardiovascular single gene disorders* cardiovascular polygenic disorders* therapies and applicationsOutstanding contributors write on their areas of expertisemaking Cardiovascular Genetics and Genomics for theCardiologist both authoritative and comprehensive. If you wantto gain a better appreciation of how genetics and genomics arealready shaping current practice and may potentially revolutionizecardiology, look no further than this dependable reference.

Contributors.Foreword.Introduction.1 The gene in the twenty-first century.Choong-Chin Liew, Victor J. Dzau.Part I: Cardiovascular single gene disorders.2 Monogenic hypercholesterolemia.Ruth McPherson.3 Hypertrophic cardiomyopathy.Ali J. Marian.4 Dilated cardiomyopathy and other cardiomyopathies.Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus.5 The long QT syndrome.Sabina Kupershmidt, Kamilla Kelemen, TadashiNakajima.Part II: Cardiovascular polygenic disorders.6 Atherosclerosis.Päivi Pajukanta, Kiat Tsong Tan, Choong-ChinLiew.7 Heart failure.Markus Meyer, Peter VanBuren.8 The implications of genes on the pathogenesis, diagnosis andtherapeutics of hypertension.Kiat Tsong Tan, Choong-Chin Liew.Part III: Therapies and applications.9 Gene therapy for cardiovascular disease: inserting new genesregulating the expression of native genes, and correcting geneticdefects.Ion S. Jovin, Frank J. Giordano.10 Stem cell therapy for cardiovascular disease.Emerson C. Perin, Guilherme V. Silva.11 Pharmacogenetics and personalized medicine.Julie A. Johnson, Issam Zineh.12 The potential of blood-based gene profiling for diseaseassessment.Steve Mohr, Choong-Chin Liew.Index.Colour plates