Vitiligo

This monograph is a comprehensive expose of the disorder vitiligo. The book introduces the topic with a presentation about its cultural effects in the Middle East where vitiligo is exceptionally disabling to the affected person. Nehru as Prime Minister of India stated that vitiligo was a major impediment to the successful development of India. The book includes sections on the definition of vitiligo based on a consensus of world experts on vitiligo. There is a complete description of its clinical manifestations including the extracutaneous sites by world experts. Differentiation of vitiligo from other forms of depigmentation associated with malignancies is included with sufficient photographs to document differences. A section will present the physiological changes associated with depigmentation - a little known phenomena. The complete histology, differential diagnosis and animal models are major sections. The animal models are important in formulating theories about the causes of vitiligo. Most clinicians will find this section very informative. The book finishes with a thorough treatise on the principles of therapy.

This monograph is a comprehensive expose of the disorder vitiligo. The book introduces the topic with a presentation about its cultural effects in the Middle East where vitiligo is exceptionally disabling to the affected person. Nehru as Prime Minister of India stated that vitiligo was a major impediment to the successful development of India. The book includes sections on the definition of vitiligo based on a consensus of world experts on vitiligo. There is a complete description of its clinical manifestations including the extracutaneous sites by world experts. Differentiation of vitiligo from other forms of depigmentation associated with malignancies is included with sufficient photographs to document differences. A section will present the physiological changes associated with depigmentation - a little known phenomena. The complete histology, differential diagnosis and animal models are major sections. The animal models are important in formulating theories about the causes of vitiligo. Most clinicians will find this section very informative. The book finishes with a thorough treatise on the principles of therapy.

List of Contributors ixForeword xiPreface xiiiPart 1: General Topics about Vitiligo1 Definition of Vitiligo 3S. K. Hann and J.J. Nordlund2 The Loss of Melanocytes from the Epidermis: the Mechanism for Depigmentation of Vitiligo Vulgaris 7J.J. Nordlund3 History and Cultural Aspects of Vitiligo 13D. Kopera4 Genetics and Prevalence of Vitiligo Vulgaris 18P.P MajumderPart 2: Clinical Presentation of Vitiligo5 Histology of Vitiliginous Skin 23R.E Boissy6 Clinical Features of Generalized Vitiligo 35S.K. Hann and J.J. Nordlund7 Clinical Features of Segmental Vitiligo 49S.K. Hann8 Childhood Vitiligo: Clinical Spectrum and Therapeutic Approaches 61P.E. Grimes and N. Billips9 Special Features of Vitiligo 70J. P. Ortonne10 Depigmentation of Hair and Mucous Membranes 76J.P. Ortonne11 Ocular and Otic Findings in Vitiligo 81M.D. Mills and D.M. Albert12 The Association of Vitiligo with Disorders of Other Organ Systems 89J.J. Nordlund and S.K. Hann13 The Psychological Effects of Vitiligo: Response to Impaired Appearance 97J. PorterPart 3: Pathogenesis of Vitiligo: Theories for Depigmentation15 The Intrinsic (Genetic) Theory for the Cause of Vitiligo 123R.E. Boissy16 Theories on the Pathogenesis of Depigmentation: Immune Hypothesis 129J.C. Bystryn17 Autocytotoxic Hypothesis for the Destruction of Melanocytes as the Cause of Vitiligo 137S.K. Hann and W.H. Chun18 Neural Pathogenesis 142G.E. Orecchia19 Biochemical Theory of Vitiligo: A Role of Pteridines in Pigmentation 151K.U. Schallreuter, W.D. Beazley and J.M. WoodPart 4: Treatment of Vitiligo20 The Melanocyte Reservoir and its Necessity 163J. Cui21 PUVA Therapy 168W.L. Morison22 Steroid Treatment for Vitiligo 173S.K. Hann23 Pseudocatalase in the Treatment of Vitiligo 182K.U. Schallreuter, J. Moore and J.M. Wood24 Surgical Therapies for Vitiligo 193R. Falabella25 Micropigmentation 202R.M. Halder26 Depigmentation for the Treatment of Extensive Vitiligo 207J.J. Nordlund27 Ancillary Therapies: Helping the Patient with Vitiligo to Adjust 214J. Porter28 Sunscreens and Sun Protection 218J.J. Nordlund29 Alternative Therapies for Vitiligo 222G.E. OrecchiaPart 5: Topics Related to Vitiligo30 Depigmentation Other Than Vitiligo 243J.C. Bystryn31 Physiological Alternatives in the Depigmented Skin of Patients with Vitiligo 254S. IM and J.J. Nordlund32 Chemical Leukoderma 269L. Miyamoto and J.S. Taylor33 Animal Models 281L. Lamoreux and R.E. BoissyIndex 299