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Autor: Gunter Mayer
ISBN-13: 9780470664018
Einband: E-Book
Seiten: 478
Sprache: Englisch
eBook Typ: PDF
eBook Format: E-Book
Kopierschutz: Adobe DRM [Hard-DRM]
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The Chemical Biology of Nucleic Acids

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With extensive coverage of synthesis techniques and applications,this text describes chemical biology techniques which have gainedsignificant impetus during the last five years. It focuses on themethods for obtaining modified and native nucleic acids, and theirbiological applications. Topics covered include:* chemical synthesisof modified RNA
* expansion of the genetic alphabet in nucleic acids by creatingnew base pairs
* chemical biology of DNA replication: probing DNA polymeraseselectivity mechanisms with modified nucleotides
* nucleic-acid-templated chemistry
* chemical biology of peptide nucleic acids (PNA)
* the interactions of small molecules with DNA and RNA
* the architectural modules of folded RNAs
* genesis and biological applications of locked nucleic acid(LNA)
* small non-coding RNA in bacteria
* microRNA-guided gene silencing
* nucleic acids based therapies
* innate immune recognition of nucleic acid
* light-responsive nucleic acids for the spatiotemporal controlof biological processes
* DNA methylation
* frameworks for programming RNA devices
* RNA as a catalyst: The Diels-Alderase-Ribozyme
* evolving an understanding of RNA function by in vitroapproaches
* the chemical biology of aptamers: synthesis andapplications
* nucleic acids as detection tools
* bacterial riboswitch discovery and analysis

The Chemical Biology of Nucleic Acids is anessential compendium of the synthesis of nucleic acids andtheir biological applications for bioorganic chemists, chemicalbiologists, medicinal chemists, cell biologists, and molecularbiologists.
Foreword.

Preface.

List of Contributors.

1 Chemical Synthesis of Modified RNA (Claudia Höbartnerand Falk Wachowius).

2 Expansion of the Genetic Alphabet in Nucleic Acids by CreatingNew Base Pairs (Ichiro Hirao and Michiko Kimoto).

3 Chemical Biology of DNA Replication: Probing DNA PolymeraseSelectivity Mechanisms with Modified Nucleotides (AndreasMarx).

4 Nucleic Acid-templated Chemistry (MichaelOberhuber).

5 Chemical Biology of Peptide Nucleic Acids (PNAs) (Peter E.Nielsen).

6 The Interactions of Small Molecules with DNA and RNA (YunXie, Victor K. Tam and Yitzhak Tor).

7 The Architectural Motifs of Folded RNAs (ValérieFritsch and Eric Westhof).

8 Genesis and Biological Applications of Locked Nucleic Acids(LNAs) (Harleen Kaur and Souvik Maiti).

9 Small Non-coding RNA in Bacteria (Sabine Brantl).

10 MicroRNA-guided Gene Silencing (Gunter Meister).

11 Nucleic Acid-based Therapies (Britta Hoehn and John J.Rossi).

12 Innate Immune Recognition of Nucleic Acids (StefanBauer).

13 Light-responsive Nucleic Acids for the Spatiotemporal Controlof Biological Processes (Alexander Heckel and GünterMayer).

14 DNA Methylation (Albert Jeltsch and Renata Z.Jurkowska).

15 Frameworks for Programming RNA Devices (Maung Nyan Win,Joe C. Liang and Christina D. Smolke).

16 RNA as a Catalyst: The Diels-Alderase Ribozyme (AndresJaschke).

17 Evolving an Understanding of RNA Function by In VitroApproaches (Qing Wang and Peter J. Unrau).

18 The Chemical Biology of Aptamers: Synthesis and Applications(Gunter Mayer and Bernhard Wulffen).

19 Nucleic Acids as Detection Tools (Jeffrey C.F. Lam, SergioAguirre and Yingfu Li).

20 Bacterial Riboswitch Discovery and Analysis (Tyler D. Amesand Ronald R. Breaker).

Index.

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Autor: Gunter Mayer
ISBN-13 :: 9780470664018
ISBN: 0470664010
Verlag: John Wiley & Sons
Seiten: 478
Sprache: Englisch
Auflage 1. Auflage
Sonstiges: Ebook