The Agile Approach to Adaptive Research

Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development. Chapters explore such subjects as: The adaptive concept Design and operational adaptations Sample-size reestimation Agile clinical development Safety and dose finding Statistics in adaptive research, including frequentist and Bayesian approaches Data management technologies The future of clinical development By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.

Apply adaptive research to improve results in drugdevelopmentThe pharmaceutical industry today faces a deepening crisis:inefficiency in its core business, the development of new drugs.The Agile Approach to Adaptive Research offers a solution.It outlines how adaptive research, using already-available toolsand techniques, can enable the industry to streamline clinicaltrials and reach decision points faster and more efficiently.With a wealth of real-world cases and examples, author MichaelRosenberg gives readers a practical overview of drug developmentthe problems inherent in current practices, and the advantages ofadaptive research technology and methods. He explains the conceptsprinciples, and specific techniques of adaptive research, anddemonstrates why it is an essential evolutionary step towardimproving drug research and development.Chapters explore such subjects as:* The adaptive concept* Design and operational adaptations* Sample-size reestimation* Agile clinical development* Safety and dose finding* Statistics in adaptive research, including frequentist andBayesian approaches* Data management technologies* The future of clinical developmentBy combining centuries-old intellectual foundations, recenttechnological advances, and modern management techniques, adaptiveresearch preserves the integrity and validity of clinical researchbut dramatically improves efficiency.