Lysophospholipid Receptors

JEROLD CHUN, MD, PhD, is a Professor at The Scripps Research Institute in La Jolla, California, and is a pioneer in the field of lysophospholipid signaling.

This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and has important, natural roles in the body including normal reproduction, development, maturation, and life. The book covers the biochemistry, interactions, and signaling of lysophospholipids as well as its potential for producing new therapies for a range of medically important human diseases. Bringing together current knowledge in lysophospholipid signaling, this book is a must-have for all academic, industrial, and medical school and hospital libraries.

PREFACE ix
 
CONTRIBUTORS xi
 
1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1
Hope Mirendil, Mu-En Lin, and Jerold Chun
 
2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41
Bongnam Jung and Timothy Hla
 
3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED FIBROBLASTS 61
Catelijne Stortelers and Wouter H. Moolenaar
 
4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE (S1P) 71
Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel
 
5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE KINASE-G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85
Nigel J. Pyne and Susan Pyne
 
6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE FUNCTIONS 103
Hiroshi Yukiura and Junken Aoki
 
7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121
Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu
 
8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY 137
Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex Brown, and Walter A. Shaw
 
9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and Stuart M. Pitson
 
10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE TRANSPORTERS 185
Atsuo Kawahara and Tsuyoshi Nishi
 
11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS 201
Ganesh Venkatraman and David N. Brindley
 
12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229
Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault
 
13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265
Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam, and Andrew J. Morris
 
14 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULAR PHYSIOLOGY AND DISEASE 283
Bodo Levkau
 
15 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE 313
Christian Waeber
 
16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPARgamma BY ENDOGENOUS LYSOPHOSPHATIDIC ACIDS (LPAS) 349
Ryoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi
 
17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OF SPHINGOSINE 1-PHOSPHATE (S1P) 373
Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell, and Joan Heller Brown
 
18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 399
Nobuyuki Fukushima
 
19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE 1-PHOSPHATE (S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THE VERTEBRATE NERVOUS SYSTEM 419
H. Meng and V.M. Lee
 
20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION AND LPA BIOSYNTHESIS 433
Hiroshi Ueda
 
21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES: IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451
Guillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela Castilla-Ortega, and Fernando Rodríguez de Fonseca
 
22 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS 475
Alejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab
 
23 BIOLOGY REVEALED BY SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR GENE-ALTERED MICE 489
Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman Kang, Catherine C. Theisen, Eleanor L. Koerner, and Richard L. Proia
 
24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE 507
C. Chris Yun and Peijian He
 
25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 529
Xiaoqin Ye
 
26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID: