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Variation in the Human Genome
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Artikel-Nr:
9780470514894
Veröffentl:
2008
Einband:
E-Book
Seiten:
340
Autor:
Derek J. Chadwick
eBook Typ:
PDF
eBook Format:
Reflowable E-Book
Kopierschutz:
Adobe DRM [Hard-DRM]
Sprache:
Englisch
Beschreibung:
The mapping of human genes is proceeding rapidly. Genes associated with specific inherited diseases are being identified, often providing insight into the molecular cause of the disease. At the moment, however, little consideration is being given to the variation present in different human populations. Variation in the Human Genome discusses methods of analysing population genetic data and how contemporary genetic heterogeneity arises during the evolution and migration of human populations. Specific disorders such as cystic fibrosis, beta-thalassaemia, fragile X, phenylketonuria and tumour development susceptibility are used to illustrate this genetic variability and mechanisms of gene mutation and evolution.
The mapping of human genes is proceeding rapidly. Genes associated with specific inherited diseases are being identified, often providing insight into the molecular cause of the disease. At the moment, however, little consideration is being given to the variation present in different human populations. Variation in the Human Genome discusses methods of analysing population genetic data and how contemporary genetic heterogeneity arises during the evolution and migration of human populations. Specific disorders such as cystic fibrosis, beta-thalassaemia, fragile X, phenylketonuria and tumour development susceptibility are used to illustrate this genetic variability and mechanisms of gene mutation and evolution.
Partial table of contents:Phyogeographic Variability in Traditional Societies (R. Ward& D. Valencia).Interpreting Genetic Variability: The Effects of SharedEvolutionary History (P. Donnelly).Microsatellites: Evolution and Mutational Processes (N. Freimer& M. Slatkin).Genetic and Geographical Variability on Cystic Fibrosis:Evolutionary Considerations (J. Bertranpetit & F.Calafell).Population Genetics of Tumours (W. Bodmer & I.Tomlinson).World Distribution of HLA Alleles and Implications for Disease(J. Bodmer).The Genetics of Common Diseses: The Implications of PopulationVariability (D. Weatherall).Final Discussion.Summary.Indexes.