Synthetic Peptides as Antigens

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Symposium on Synthetic Peptides as Antigens, held at the CibaFoundation, London, 4-6 June 1985The subject of this symposium was proposed by P. Dukor and D. G.BraunEditors: Ruth Porter (Organizer) and Julie WhelanG. L. Ada IntroductionJ. H. Humphrey Regulation of in vivo immune responses: fewprinciples and much ignoranceDiscussionP. J. Lachmann, L. Strangeways, A. Vyakarnam and G. I. EvanRaising antibodies by coupling peptides to PPD and immunizingBCG-sensitized animalsDiscussionH. J. Dyson, K. J. Cross, J. Ostresh, R. A. Houghten, I. A.Wilson, P. E. Wright and R. A. Lerner Selection by site-directedantibodies of small regions of peptides which are ordered inwaterDiscussionM. H. V. Van Regenmortel, D. Altschuh and A. Klug Influence oflocal structure on the location of antigenic determinants intobacco mosaic virus proteinDiscussionM. J. Crumpton The importance of conformation and of equilibriain the interaction of globular proteins and their fragments withantibodiesDiscussionA. B. Edmundson and K. R. Ely Three-dimensional analyses of thebinding of synthetic chemotactic and opioid peptides in the Mcglight chain dimerDiscussionH. M. Geysen, S. J. Rodda and T. J. Mason The delineation ofpeptides able to mimic assembled epitopesDiscussionV. Nussenzweig and R. S. Nussenzweig Experimental basis for thedevelopment of a synthetic vaccine against Plasmodium falciparummalaria sporozoitesDiscussionR. F. Anders, P-T. Shi, D. B. Scanlon, S. J. Leach, R. L.Coppel, G. V. Brown, H-D. Stahl and D. J. Kemp Antigenic repeatstructures in proteins of Plasmodium falciparumDiscussionM. Sela, R. Arnon and C. O. Jacob Synthetic peptides withantigenic specificity for bacterial toxinsDiscussionV. C. Stevens Use of synthetic peptides as immunogens fordeveloping a vaccine against human chorionic gonadotropinDiscussionD. R. Stanworth, D. S. Butt and G. Z. Hastings The use ofsynthetic peptides in the delineation of immunoglobulin antigenicepitopes and Fc effector functionsDiscussionG. I. Evan, D.C. Hancock, T. Littlewood and C. D. PauzaCharacterization of the human c-myc protein using antibodiesprepared against synthetic peptidesDiscussionS. S. Alkan and D. G. Braun Epitope mapping of human recombinantinterferon alpha molecules by monoclonal antibodiesDiscussionFinal general discussion Reactivity of anti-peptide antibodieswith the parent proteinsThe proportion of monoclonal antibodies reactive toconformational or other linear sequencesHigh and low affinity antibodies and their rolesT-dependent and T-independent antigen presentationG. L. Ada Chairman's summing-upIndex of contributorsSubject index