Drug Efficacy, Safety, and Biologics Discovery

Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.

Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.

Preface.Acknowledgments.Contributors.PART I: DRUG EFFICACY AND SAFETY TECHNOLOGY.1. Focus on Fundamentals: Towards Better Therapeutic IndexPrediction (Jinghai J. Xu and Li J. Yu).2. High-Throughput Protein-Based Technologies and ComputationalModels for Drug Development, Efficacy and Toxicity (Leonidas G.Alexopoulos, Julio Saez-Rodriguez and Christopher W. Espelin).3. Cellular Systems Biology Applied to Pre-Clinical SafetyTesting: A Case Study of CellCiphr¯TMProfiling (Lawrence Vernetti, William Irwin, Kenneth A. GiulianoAlbert Gough, Kate Johnston and D. Lansing Taylor).4. Systems Pharmacology, Biomarkers and Biomolecular Networks(Aram Adourian, Thomas N. Plasterer, Raji Balasubramanian, EzraJennings, Shunguang Wang, Jan van der Greef, Robert McBurneyPieter Muntendam, and Noubar Afeyan).5. Zebrafish Models for Human Diseases and Drug Discovery(Hanbing Zhong, Ning-Ai Liu and Shuo Lin).6. Toxicity Pathways and Models: Mining for Potential SideEffects (Sean Ekins and Josef Scheiber).7. Computational Systems Biology Modeling of Dosimetry andCellular Response Pathways (Qiang Zhang, Yu-Mei Tan, SudinBhattacharya and Melvin E. Andersen).8. Stem Cell Technology for Embryotoxicity, Cardiotoxicity andHepatotoxicity Evaluation (Julio C. Davila, Donald B. StedmanSandra J. Engle, Howard I. Pryor II and Joseph P. Vacanti).9. Telemetry Technology for Preclinical Drug Discovery andDevelopment (Yi Yang).PART II. BIOLOGICS TECHNOLOGY.10. Nanotechnology to Improve Oral Drug Delivery (Mayank D.Bhavsar, Shardool Jain, and Mansoor M. Amiji).11. Functional Glycomics and the Future of Glycomic Drugs (RamSasisekharan).12. Modeling Efficacy and Safety of Engineered Biologics (JeffChabot and Bruce Gomes).13. Regulation of Gene Expression by Small, Non-Coding RNAs:Practical Applications (Roman Herrara and Eric Tien).PART III. FUTURE PERSPECTIVE.14. Future Perspectives of Biological Engineering inPharmaceutical Research: The Paradigm of Modeling, MiningManipulation and Measurements (Jinghai J. Xu, Sean Ekins, MichaelMcGlashen and Douglas Lauffenburger).Index.