Acute Ischemic Stroke

This focused book deals clearly and concisely with the principlesof management of patients with acute ischemic stroke (AIS). Itemphasizes the published and verifiable evidence in support ofthese principles, and highlights the areas of limited evidence.Best evidence is provided for the current standard treatment ofacute ischemic stroke, including intravenous chemical thrombolysis,intra-arterial approaches, blood pressure management, andanti-thrombotic therapy. More modern techniques are also described,such as the use of mechanical devices to evacuate a thrombus,induced hypertension, hyper-oxygenation (hyperoxia), andneuroprotective or neuroregeneration agents. Hallmark featuresinclude:* Focused on acute ischemic stroke, the most rapidly growing areaof stroke management* Evidence based: Provides best evidence for treatment* Clearly discusses areas and topics where best evidence has notyet been established* Lays out treatment plans and protocols in handbook fashion forease of use and reference, even in emergency situations* Includes latest and cutting-edge techniques and equipment fordealing with AISAcute Ischemic Stroke: An Evidence-based Approach is anindispensable reference work for neurologists, neurocritical caremedics, intensivists, hospitalists, emergency room physicians,neurology residents and fellows. It is also a helpful resource formedical students, physician assistants, and nurse practitioners inhospital and neurocritical care facilities.

Preface viiContributors ix1. Stroke: Historical Perspectives and Future Directions 1Magdy Selim, MD, PhD2. Neuroimaging of the Acute Stroke Patient 3William A. Copen, MD, and Michael H. Lev, MD3. Intravenous Thrombolysis 39Sherry H.-Y. Chou, MD, and Eric E. Smith, MD, MPH, FRCPC4. Endovascular Approaches to Acute Stroke 63Raul G. Nogueira, MD, Guilherme C. Dabus, MD, Joshua A. Hirsch, MD, and Lee H. Schwamm, MD5. Nonthrombolytic Acute Stroke Therapies 97Aneesh B. Singhal, MD, Larami MacKenzie, MD, and Joshua M. Levine, MD6. Surgical Management of Acute Stroke Patients 123Alim P. Mitha, MD, Carlos E. Sanchez, MD, and Christopher S. Ogilvy, MD7. Antithrombotic Therapy for Acute Stroke 137Orla Sheehan, MD, BAO, BCh, MRCPI, and Peter Kelly, MD, MS, FRCPI8. Intensive Care Management of Acute Ischemic Stroke 163Kevin N. Sheth, MD, and David M. Greer, MD, MA9. Evaluation of Acute Stroke Etiologies 197Karen L. Furie, MD, MPH, Michael H. Lev, MD, Walter J. Koroshetz, MD, and David M. Greer, MD, MA10. TeleStroke: Application of Telemedicine in Acute Ischemic Stroke 213Eric S. Rosenthal, MD, and Lee H. Schwamm, MDIndex 233