Fundamental Medical Mycology

Errol Reiss, Ph.D., is Adjunct Professor of Microbiology at Emory University School of Medicine (EUSM), Atlanta, Georgia, and Research Microbiologist, Molecular Typing Unit, Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases in the Centers for Disease Control and Prevention, Atlanta, Georgia. Department of Microbiology and Immunology. Dr. Reiss previously published a single-author textbook in the field of medical mycology (see below) and has published several book chapters, review articiles and a total of? 87 primary research literature publications.

Medical mycology deals with those infections in humans, and animals resulting from pathogenic fungi. As a separate discipline, the concepts, methods, diagnosis, and treatment of fungal diseases of humans are specific. Incorporating the very latest information concerning this area of vital interest to research and clinical microbiologists, Fundamental Medical Mycology balances clinical and laboratory knowledge to provide clinical laboratory scientists, medical students, interns, residents, and fellows with in depth coverage of each fungal disease and its etiologic agents from both the laboratory and clinical perspective. Richly illustrated throughout, the book includes numerous case presentations.

- In depth coverage of each fungal disease and its etiologic agents from both the laboratory and clinical perspective. - Each chapter follows a single format for greater consistency.

Preface xvii
 
Acknowledgments xix
 
Part One Introduction to Fundamental Medical Mycology, Laboratory Diagnostic Methods, and Antifungal Therapy
 
1. Introduction to Fundamental Medical Mycology 3
 
1.1 Topics not Covered, or Receiving Secondary Emphasis 3
 
1.2 Biosafety Considerations: Before You Begin Work with Pathogenic Fungi... 3
 
1.3 Fungi Defined: Their Ecologic Niche 5
 
1.4 Medical Mycology 5
 
1.5 A Brief History of Medical Mycology 6
 
1.6 Rationale for Fungal Identification 9
 
1.7 Sporulation 11
 
1.8 Dimorphism 11
 
1.9 Sex in Fungi 13
 
1.10 Classification of Mycoses Based on the Primary Site of Pathology 13
 
1.11 Taxonomy/Classification: Kingdom Fungi 14
 
1.12 General Composition of the Fungal Cell 21
 
1.13 Primary Pathogens 25
 
1.14 Endemic Versus Worldwide Presence 26
 
1.15 Opportunistic Fungal Pathogens 26
 
1.16 Determinants of Pathogenicity 27
 
2. Laboratory Diagnostic Methods in Medical Mycology 31
 
2.1 Who Is Responsible for Identifying Pathogenic Fungi? 31
 
2.2 What Methods are Used to Identify Pathogenic Fungi? 31
 
2.3 Laboratory Detection, Recovery, and Identification of Fungi in the Clinical Microbiology Laboratory 33
 
2.4 Genetic Identification of Fungi 64
 
3A. Antifungal Agents and Therapy 75
 
3B. Antifungal Susceptibility Tests 107
 
Part Two Systemic Mycoses Caused by Dimorphic Environmental Molds (Endemic Mycoses)
 
4. Blastomycosis 125
 
4.1 Blastomycosis-at-a-Glance 125
 
4.2 Introduction/Disease Definition 125
 
4.3 Case Presentations 126
 
4.4 Diagnosis 127
 
4.5 Etiologic Agent 127
 
4.6 Geographic Distribution/Ecologic Niche 128
 
4.7 Epidemiology 129
 
4.8 Risk Groups/Factors 129
 
4.9 Transmission 129
 
4.10 Determinants of Pathogenicity 130
 
4.11 Clinical Forms 131
 
4.12 Veterinary Forms 133
 
4.13 Therapy 133
 
4.14 Laboratory Detection, Recovery, and Identification 134
 
5. Coccidioidomycosis 141
 
5.1 Coccidioidomycosis-at-a-Glance 141
 
5.2 Introduction/Disease Definition 141
 
5.3 Case Presentations 142
 
5.4 Diagnosis 143
 
5.5 Etiologic Agents 143
 
5.6 Geographic Distribution / Ecologic Niche 144
 
5.7 Epidemiology 147
 
5.7.1 Incidence and Prevalence 147
 
5.8 Risk Groups / Factors 149
 
5.9 Transmission 150
 
5.10 Determinants of Pathogenicity and Pathogenesis 151
 
5.11 Clinical Forms 155
 
5.12 Veterinary Forms 156
 
5.13 Therapy 156
 
5.14 Laboratory Detection, Recovery, and Identification 158
 
6. Histoplasmosis 165
 
6.1 Histoplasmosis-at-a-Glance 165
 
6.2 Introduction / Disease Definition 165
 
6.3 Case Presentations 166
 
6.4 Etiologic Agents 169
 
6.5 Geographic Distribution/Ecologic Niche 170
 
6.6 Epidemiology 171
 
6.7 Transmission 171
 
6.8 Determinants of Pathogenicity 172
 
6.9 Clinical Forms 175
 
6.10 Veterinary Forms 178
 
6.11 Therapy 179
 
6.12 Laboratory Detection, Recovery, and
 
7. Paracoccidioidomycosis 187
 
7.1 Paracoccidioidomycosis-ata-Glance 187
 
7.2 Introduction/Disease Definition 187
 
7.3 Case Presentation 188
 
7.4 Etiologic Agent 188
 
7.5 Geographic Distribution/Ecologic Niche 189
 
7.6 Epidemiology 189
 
7.7 Transmission 191
 
7.8 Determinants of Pathogenicity