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The Design of Studies for Medical Research
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Artikel-Nr:
9780470012987
Veröffentl:
2005
Einband:
E-Book
Seiten:
286
Autor:
David Machin
eBook Typ:
PDF
eBook Format:
Reflowable E-Book
Kopierschutz:
Adobe DRM [Hard-DRM]
Sprache:
Englisch
Beschreibung:
The same careful rigour imposed on the design of phase III randomised controlled trials is not always applied to medical research in other areas such as trials conducted at earlier stages of drug development. With the emphasis that is now placed on evidence-based medicine, such care and rigour will inevitably impact on these areas with increasing attention turned to the quality of design. This title describes what principles can be used to structure research effectively allowing for the required degree of accuracy. Written by two best selling authors, this book includes many examples from medical literature and will be of great value to all groups conducting studies at the interface of clinical and laboratory research.
The same careful rigour imposed on the design of phase IIIrandomised controlled trials is not always applied to medicalresearch in other areas such as trials conducted at earlier stagesof drug development.With the emphasis that is now placed on evidence-based medicinesuch care and rigour will inevitably impact on these areas withincreasing attention turned to the quality of design.This title describes what principles can be used to structureresearch effectively allowing for the required degree ofaccuracy.Written by two best selling authors, this book includes manyexamples from medical literature and will be of great value to allgroups conducting studies at the interface of clinical andlaboratory research.
Preface.Chapter 1. What is Evidence.Chapter 2. Measurement, Forms and Questionnaires.Chapter 3. Principles of Study Size Calculation.Chapter 4. Randomisation.Chapter 5. Cross-sectional Longitudinal Studies.Chapter 6. Surveys, Cohort and Case-Control Studies.Chapter 7. Clinical Trails - General Issues.Chapter 8. Early Clinical Trials.Chapter 9. Phase III Trials.Chapter 10. Diagnosis.Chapter 11. Prognostic Factor Studies.References.Tables.Index.