Neuropsychiatric Disorders and Epigenetics

Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy.

Section I. Neuropsychiatric Disorders and Epigenetics: General Aspects1. Introduction to Neuropsychiatric Disorders and Epigenetics2. Environmental Factors and Epigenetics of Neuropsychiatric Disorders3. Epigenetic Biomarkers in Neuropsychiatric Disorders4. Epigenetics and Neuroimaging in Neuropsychiatric Disorders5. Recent advances in genome-wide approaches to biomedical research6. Single Cell Epigenomic Approaches in Neuropsychiatric Disorders7. Neuropsychiatric Disorders and Epigenetics: Computational Approaches; Sampling methods; and Power analysesSection II: Epigenetics of Neuropsychiatric Disorders 8. Epigenetics and Cognitive Disorders -Translational Aspects9. Epigenetics in Autism Spectrum Disorders - Translational Aspects10. Epigenetic causes of intellectual disability ¿ the fragile X syndrome paradigm11. Epigenetics of Attention-Deficit Hyperactivity Disorder12. The epigenetics of brain aging and psychiatric disorders13. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene products14. Epigenetics and Multiple Sclerosis15. Epigenetics and Migraine16. The role of epigenetics in the pathophysiology of epilepsy17. Epigenetic Dysregulation in Brain Tumors and Neurodevelopment18. Epigenetics and Cerebrovascular Diseases19. Epigenetics of Spinal Muscular Atrophy and the Potential Role of Epigenetics in the Treatment of this Disorder20. Epigenetics and Anxiety Disorders21. Epigenetics and Eating Disorders22. Epigenetics in Obesity23. Epigenetics and Drug Addiction-Translational Aspects24. Epigenetics and Alcohol Use DisordersSection III: Summary and Outlook25. Summary and Outlook