Heart Failure in the Child and Young Adult

Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure and then progresses through diagnosis, management, treatment, and surgery, finally concluding with advanced special topics, including genetics, self-management, and nanomedicine. This new edition covers advancements in the field, including additional chapters and discussion on biomarkers, neuromuscular disease, quality of life, palliative care, and the impact of COVID-19 in myocarditis and multisystem inflammatory syndrome in children. It will serve as an indispensable reference to basic science researchers in cardiology, pediatrics, cardiologists, and pediatric cardiologists.

Section I: Basic Science of Heart Failure1. Molecular and Cellular Mechanisms in Heart Failure including Models of Heart Failure2. Cardiovascular Receptors and Signaling in Heart Failure3. Inflammatory Mediators in Heart Failure4. Epigenetics and Transcriptomics5. Mechanisms of Hypertrophy in Heart Failure6. Hemodynamic Adaptive Mechanisms in Heart Failure7. Neurohormonal Axis and Natriuretic Peptides in Heart Failure8. Biomarkers in Heart Failure9. Mechanisms of systolic and diastolic dysfunction10. Echocardiographic Quantitation of Ventricular Function11. Magnetic Resonance Imaging Assessment of Heart Failure12. Assessment of Heart Failure by Invasive Methods13. Lymphatic System in Heart Failure14. Endothelial DysfunctionSection II: Clinical Diagnosis and Management of Pediatric Heart Failure15. Epidemiology and Economic Aspects of Pediatric Heart Failure16. Clinical Recognition of Heart Failure in Children17. Classification of Heart Failure18. Right Ventricular Dysfunction19. Pediatric Myocarditis20. Dilated Cardiomyopathy21. Clinical Features of Restrictive Cardiomyopathy and Constrictive Pericarditis22. Hypertrophic Cardiomyopathy23. Left Ventricular Noncompaction24. Arrhythmogenic Cardiomyopathies25. Valvular Insufficiency and Heart Failure26. Valvular Stenosis and Heart Failure27. Coronary Artery Disease in Children and Young Adults28. Heart Failure in Congenital Heart Disease Including Single Ventricle Circulation29. Heart Failure in Adults with Congenital Heart Disease30. Dysrhythmias and Ventricular Dysfunction and Heart Failure31. Heart Failure in the Fetus32. Heart Failure in the Neonate33. Heart Failure in Pediatric Pulmonary Diseases34. Cardiorenal Syndrome35. Heart Failure in Pediatric Oncologic Disease36. Neuromuscular Diseases37. Sickle Cell Disease38. The Cardiovascular System in Systemic Inflammatory Syndromes39. Outpatient Management40. Cardiac Intensive Care and Inpatient Management41. Quality of Life and Psychosocial Care42. Palliative Care43. Quality Improvement and Learning Collaboratives44. Nursing Aspects of Heart FailureSection III: Medical Treatment for Pediatric Heart Failure45. Diuretics and Invasive Fluid Management Strategies46. Inotropic Agents in Heart Failure47. Phosphodiesterase Inhibitors48. Inhibition of the Renin-Angiotensin-Aldosterone System and Other Vasodilators49. Beta-adrenergic Receptor Blockade50. Low Cardiac Output Syndrome in the Intensive Care Setting51. New Therapeutic Strategies in Heart Failure52. Electrophysiologic Devices in Heart Failure53. Catheter Device Therapy for Heart FailureSection IV: Cardiac Surgery and Pediatric Heart Failure54. Post-Transplant Heart Failure55. Surgical Strategies for the Failing Systemic Ventricle56. Valve Intervention for Valve Failure57. General Principles of Mechanical Cardiopulmonary Support58. Short-Term Mechanical Cardiopulmonary Support Devices59. Decision Making in Ventricular Assist Device Support in Pediatric Patients60. Long-Term Ventricular Assist Devices and Destination Therapy61. Future of Mechanical Support Devices in Children and Young AdultsSection V: Special Topics62. Genetics and Genomics63. Genetic Testing64. Data Management and Analytics65. Self-Management and Outpatient Monitoring66. Regenerative Medicine67. Nanomedicine68. Digital Twin and Innovation in Research Design69. Nutritional Assessment and Management in Pediatric Heart Failure