Breast Cancer Risk Reduction and Early Detection

While many comprehensive texts have been written on the treatment of breast cancer, the most common cancer among women, there are relatively few which cover in depth the prevention and early detection of the disease. The goal of this work is to present what experts in the ?eld feel is the current knowledge and future direction of breast cancer prevention and early detection. We begin Part I of the book with a review of risk factors, both genetic and environmental. We next review progress in the use of chemoprevention. Notably, chemoprevention risk reduction studies have led to FDA approval of two medications which measurably reduce disease incidence among women at increased risk, although with some risk of treatment related side effects. Newer agents in the pipeline, which may also reduce risk among normal risk women, are also discussed. Surgical risk reducing strategies complete the section on prevention, including both the bene?ts and downsides to this more aggressive approach. Even with aggressive prevention strategies, some women will develop breast cancer. For these women, early detection is critical to minimize disease spread and maximize long term survival. Part II of this book reviews current and upcoming approaches to early detection. Imaging strategies, including mammography, breast ultrasound, MRI, and PET imaging are reviewed. The potential for molecular tumor targeting to detect disease prior to the formation of a mass visible by anatomic imaging is presented.

Includes supplementary material: sn.pub/extras

I: PREVENTION.- Risk Factors.- Lifestyle Factors and Risk of Breast Cancer: A Review of Randomized Trial Findings.- Breast Cancer Chemoprevention.- Surgical Management of Inherited Susceptibility to Breast Cancer.- II: EARLY DETECTION.- Clinical Breast Examination and Breast Self-Examination.- Mammography.- Current Status and Future Prospects in Breast Carcinoma of Positron Emission Tomography.- Breast MRI.- Genetic and Molecular Approaches to Imaging Breast Cancer.- Intraductal Approaches: Nipple Aspirate Fluid to Assist in Breast Cancer Detection.- Intraductal Approaches: Mammary Ductoscopy and Ductal Lavage to Assist in the Diagnosis of Breast Cancer.- Blood Markers.- Circulating Tumor Cells in Breast Cancer.