Beschreibung:
If you reveal your secrets to the wind, you should not blame the wind for revealing them to the trees. —From The Prophet by Kahlil Gibran This was a very satisfying book to write, but also perhaps a very dangerous one. After 15 years of building a base of knowledge in radiopharmaceutical dosimetry (under the expert guidance of Evelyn Watson at the Oak Ridge Dosimetry Center), 8 years of teaching radiation protection and dosimetry at the university level (in northeastern Brazil and at Vanderbilt University in the United States), and Photo used with permission. Copyright © OregonVacationBeaches.com. Also see Memorable-Beach-Vacations.com. v vi Preface authoring a number of papers and book chapters on the subject, it was rewarding to write down in a single, organized text nearly all that I have learned on this topic. My deepest desire is that this text will be found useful by members of the nuclear medicine and radiation protection community in formalizing and facilitating such calculations. After learning a technique for performing dose calculations that must be done often, I have often found ways to automate such work in software tools and to make such tools available to others in order to help them shortcut their efforts. One of the greatest rewards I have received in my work has been to see a few of the tools and ideas that I have developed become useful to others in their routine work.
Written by a leading international authority in the field, this book is a practical introduction that guides the reader through fundamental concepts in the calculation of radiation dose. It includes discussion of the biological effects of radiation on living systems.
Written by a leading international authority in the field, this book is ideal for physicians and residents in nuclear medicine who want to improve their knowledge in internal dosimetry. The text is a practical introduction that guides the reader through fundamental concepts in the calculation of radiation dose, including discussions of standardized models, methods of calculations, and available software applications. This comprehensive guide discusses too the biological effects of radiation on living systems. The book also includes an overview of regulatory aspects related to the radiation dosimetry of new radiopharmaceuticals.
Uses of Dosimetry Information in Nuclear Medicine.- Diagnostic vs. Therapeutic Applications.- Model-Based vs. Patient-Based Approaches.- Practical Dosimetry: Balancing Benefits and Risks.- Clinical Utility: Interface of pPtient, Physician, and Physicist. Fundamental Concepts: Calculating Radiation Dose.- Dosimetry Quantities and Units.- Dosimetry Systems. Models and Resources for Internal Dose Calculations.- Standardized Models for Dosimetry.- Input Data for Dose Calculations.- Standard Dose Estimates for Radiopharmaceuticals.- Modifications to the Standard Models.- The Pregnant Patient.- The Breastfeeding Patient. Steps in Dose Calculations.- Choice and Application of Standardized Models.- Internal Dose Calculations.- Image Quantification: Human Data.- Kinetic Analysis.- Dose Calculations.- Teaching Examples.- Image-Based, Patient-Individualized Dosimetry. Case Studies.- Development of New Diagnostic Radiopharmaceuticals.- Development of Radiopharmaceuticals for Therapy.- The Pregnant Patient. Biological Effects of Radiation.- Basic Principles.- Mechanisms of Radiation Damage to Biological Systems.- Observed Biological Effects in Humans.- Cancer.- Cell Survival Studies.- Related Biological Effectiveness.- New Evidence: and Some Confusion!.- Use of Radiation Dosimetry in Patient Therapy Treatment Planning. Regulatory Aspects of Dose Calculations.- The Philosophy of Radiation Protection.- Scientific Advisory Bodies.- Regulatory Bodies.
