Pathology of the Human Placenta, 5th Edition

Pathology of the Human Placenta, 5th Edition
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Kurt Benirschke
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Most obstetricians and pediatricians would agree that the examination of the placenta often helps to explain an abnormal neona tal outcome. As early as in 1892, Ballantyne wrote, A diseased foetus without its placenta is an imperfect specimen, and a description of a foetal malady, unless accompanied by a notice of the placental condition, is incomplete. Deductions drawn from such a case cannot be considered as conc- sive, for in the missing placenta or cord may have existed the cause of the disease and death. During intrauterine life the foetus, the membranes, the cord and the placenta form an organic whole, and disease of any part must react upon and affect the others. Similar thoughts were succinctly detailed in Price’s (1950) discussion of his concept of the prenatal biases as they affected twins. His contribution also admonishes us that placental study is a sine qua non for a more perfect understanding of fetal development. Despite all this understanding of the past and appreciation for plac- tal disease, great resistance still exists to perform the task of placental examination routinely. For many pathologists, therefore, the placenta has remained a mysterious organ.

The fifth edition of Pathology of the Human Placenta will ensure this book remains the authoritative text in the field. This fifth edition reflects new advances in the field and includes 800 illustrations, 173 of them in color.

Pathology of the Human Placenta remains the authoritative text in the field and is respected and used by pathologists and obstetrician-gynecologists alike. This fifth edition reflects new advances in the field and includes 800 illustrations, 173 of them in color. The detailed index has been improved and the tables updated. Defined terms are highlighted in bold for easy identification, and further findings are discussed in small type throughout each chapter. Advances in genetics and molecular biology continue to make the study of the placenta one of vast diagnostic and legal importance.

Examination of the Placenta.- Macroscopic Features of the Delivered Placenta.- Microscopic Survey.- Placental Types.- Early Development of the Human Placenta.- Basic Structure of the Villous Trees.- Architecture of Normal Villous Trees.- Characterization of the Developmental Stages.- Nonvillous Parts and Trophoblast Invasion.- Involution of Placental Site: Retained Placenta.- Anatomy and Pathology of the Placental Membranes.- Anatomy and Pathology of the Umbilical Cord.- Placental Shape Aberrations.- Histopathologic Approach to Villous Alterations.- Classification of Villous Maldevelopment.- Erythroblastosis Fetalis and Hydrops Fetalis.- Transplacental Hemorrhage, Cell Transfer, Trauma.- Fetal Storage Disorders.- Maternal Diseases Complicating Pregnancy: Diabetes, Tumors, Preeclampsia, Lupus Anticoagulant.- Infectious Diseases.- Abortion, Placentas of Trisomies, and Immunologic Considerations of Recurrent Reproductive Failure.- Molar Pregnancies.- Trophoblastic Neoplasms.- Benign Tumors and Chorangiosis.- Multiple Pregnancies.- Legal Considerations.

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