Sinusoidal Cells in Liver Diseases

Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers, and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics. Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure.

Section 1 The liver sinusoid - General concepts 1. The unique architecture of the hepatic sinusoid 2. Sinusoidal cells interactions - from soluble factors to exosomes 3. Sinusoidal cells and liver immunology 4. Microscopic imaging of the hepatic sinusoid 5. The liver sinusoid at single cell level 6. Advanced models to study the liver sinusoid 7. Aging and the liver sinusoid