Arrestins

Dr. Gurevich obtained his PhD at the Shemyakin Institute of Bioorganic Chemistry, in Moscow, Russia. He performed his postdoctoral studies at Thomas Jefferson University in Philadelphia and is currently Professor of Pharmacology at Vanderbilt University. He is a Cornelius Vanderbilt Endowed Chair. He has published more than 220 papers in reputed journals and has been serving as an editorial board member of several journals. The main focus of the work in his lab is structure-function studies of arrestins, that bind almost all of >800 G protein-coupled receptors in humans and dozens of non-receptor signaling proteins. The lab is using biochemistry, biophysics, and cell biology to elucidate arrestin elements involved in the interactions with various binding partners and to construct signaling-biased arrestins specifically targeting individual receptors and signaling pathways.

Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins.

1. History of Arrestins
2. Basic Principles of G Protein-Coupled Receptor signaling
3. Structural Basis of Arrestin-GPCR Interactions
4. Non-Visual Arrestins: Mechanisms of Arrestin Activation and Arrestin-Dependent Signaling
5. Mechanisms of Arrestin-Mediated JNK Activation
6. Mechanisms of Arrestin-Dependent Facilitation of ERK Signaling
7. Visual Arrestins in Photoreceptor Function and Visual Disorders
8. Arrestins in GPCR Endocytosis
9. Arrestins as therapeutic Targets
10. Introducing Bias into GPCR-Dependent and Independent Arrestin Signaling by Protein Engineering