Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research

th This volume contains selected lectures presented at the 12 International Conference on Advances in Prostaglandin, Leukotriene and Other Bioactive Lipid Research: Basic Science and Clinical Applications which was held in Istanbul, Turkey, on August 25-29, 2002. This meeting brought together basic and clinical scientists for the purpose of discussing advances in bioactive lipid research with.special attention to cancer, cardiovascular diseases, gastrointestinal diseases and respiratory diseases. Topics covered included: the role of leukotrienes and lipoxins in of inflammation, the cytochrome P450 pathway, the genetics and genomics bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors. Sessions included plenary lectures with expertise in particular areas, oral presentation on selected topics and general poster sessions. J.M. Drazen (Boston, USA) discussed anti-leukotriene treatment in asthma patients while C. Brink (paris, France) presented the recent advances in leukotriene receptors. The recent advances in cytochrome p450 pathway described in the session organized by J.C. McGiff (Valhalla, NY, USA). T. Shimizu (Tokyo, Japan) and M. Balazy (Valhalla, NY, USA) gave an update on phospholipases and arachidonic acid peroxydation. The editors are greatful to the Organizing, Programme and Advisory Committees for their valuable contributions. We greatfully acknowledge the generous financial support provided by PharmaciaIPfizer, Fako Pharmaceuticals Inc. and Novartis Pharmaceuticals Inc. ofthe contributors to this volume, in particular We are also greatful to all to those who delivered their manuscripts by or before the requested deadline.

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Leukotrienes and Lipoxins: Inflammation and Asthma.- 1. Leukotrienes in Asthma.- 2. Leukotriene Receptors: State of the Art.- 3. LTC4 Production by Eosinophils in Asthmatic Subjects with Alternative Forms of Alox-5 Core Promote.- 4. II-4-Induced Lipid Mediators Class Switching in Human Normal Mononuclear Phagocytes.- 5. Lipoxins and Aspirin-Triggered Lipoxins in Airway Responses.- 6. Potential Role of Cysteinyl Leukotrienes in Trafficking and Survival of Hematopoietic Progenitor Cells.- 7. Covalent Binding of Leukotriene A4 to Nucleosides, Nucleotides, and Nucleic Acid.- 8. Firm Adhesion of Neutrophils to Cerebral Vascular Endothelium "In Vivo": A Role for Cys-Leukotrienes.- Cytochrome P450 Pathway.- 9. The CYP P450 Arachidonate Monooxygenases: Enzymatic Relays for the control of Kidney Function and Blood Pressure.- 10. Cytochrome P450-Derived Eicosanoids are Mediators of Ocular Surface Inflammation.- 11. Regulation of Renal Microvascular 20-Hydroxyeicosatetraenoic Acid (20-Hete) Levels.- 12. Cyclooxygenase Activity is Regulated by the Heme Oxygenase System in Microvessel Endothelial Cells.- 13. Cytochrome P450 Arachidonic Acid Metabolites Modulate Renal Tubular Function.- Receptors and Inhibitors.- 14. Thromboxane-induced ERK Phosphorylation in Human Aortic Smooth Muscle Cells.- 15. Arachidonic Acid Inhibits Cysteinyl-Leukotriene Receptor Activation In Human Pulmonary Vessels.- Phospholipases and Inhibitors.- 16. Cytosolic Phospholipase A2? in Mouse Platelet.- 17. Cellular Arachidonate-Releasing Functions of Various Phospholipase A2.- 18.Biological Functions of Group X Secretory PLA2.- 19. Protection of Cell Membrane from Exogenous PLA2 and Related Inflammatory Stimuli by Membrane-Anchored Lipid Conjugate.- Prostaglandin Synthases and Receptor Signaling.- 20.Regulatory Functions of Prostaglandin E2 Synthase.- 21. A Novel Type of Membrane-Associated Prostaglandin E Synthase.- 22. Expression, Purification and Characterization of Recombinant Human Microsomal PGE2 Synthase-.- Cyclooxygenase and Lipoxygenase Pathways and Inhibitors.- 23. Formation of Prostaglandin E2, Leukotriene B4 and 8-Isoprostane in Alveolar Macrophages by Ultrafine Particles of Elemental Carbo.- 24. Effects of PGF2? Analogues in Experimental Morphine-Induced Pharmacodependenc.- 25. Inhibition of Prostaglandin H2 Synthases by Salicylate is Dependent on the Oxidative State of the Enzyme.- 26. 5-Lipoxygenase Activation by MAPKAPK-2 and ERKs O. Werz.- 27. Renal Effects of Selective Cyclooxygenase Inhibition in Experimental Liver Disease.- 28. Variable Antipyretic Effect of SC-58236, a Selective Cyclooxygenase (COX)-2 Inhibitor, in Rats.- Genetics and Genomics.- 29. Induction of Cyclooxygenase-2 Expression by Fluid Shear Stress in Vascular Endothelial Cells.- 30. Induction of COX-2 Expression by the Endocannabinoid Derivative R(+)-Methanandamide.- 31. Specific Gene Expression of Isoforms in Cyclooxygenase Pathway to Generate PGJ2 Derivatives During the Differentiation of 3t3-Ll Adipocyte.- 32. Tristetrapolin Binds to the COX-2 MRNA 3' Untranslated Region in Cancer Cells.- 33. Platelet Activating Factor Receptors.- 34. Splicing Mutation of the Prostacyclin Synthase Gene in a Family Associated with Hypertension.- 35. DNA Methylation Regulates 5-Lipoxygenase Promoter Activity.- Lipid Peroxidation, Apoptosis and Fatty Acids.- 36. Isomerization and Nitro-Oxidation of Arachidonic Acid by NO2.- 37. Prostaglandin F2? Protected Cultured Madin-Darby Canine Kidney Cells from the Development of Apoptosis Induced by 12-O-Tetradecanoyl Phorbol-?-Acetate and StimulatedSynergistically with Nordihydroguaiaretic Aci.- 38. LDL Receptor-Related Protein Plays an Essential Role in 12/15- Lipoxygenase-Mediated LDL Oxidation by Macrophages.- 39. Effects of in vitro Exposure to Carbon Dioxide on the Expression of Apoptosis-Associated Genes in Human Peritoneal Fibroblasts.- 40. Identification, Characterization, and Properties of a Class Alpha Microsomal Glutathione S-Transferase.- Cardiovascular System.- 41. Cyclooxygenase (COX) Function in The Ductus Arteriosus: Another Look.- 42. Evidence for Enhanced Oxidative Stress in Coronary Heart Disease and Chronic Heart Failure.- Angiogenesis and Cancer.- 43. The Leukotriene Receptor CYSLT1 and 5-Lipoxygenase are Upregulated in Colon Cance.- 44. Increased Expression of 5-Lipoxygenase in Glioblastoma Multiforme.- Isoprostanes.- 45. Variable Influence of Statins on Isoprostanes in Hyperlipidemia.- 46. Increased Isoprostanes in Children of Smoking Parents.- 47. The Dinor Isoprostane Pathway in Plants.