Tryptophan, Serotonin, and Melatonin

Dr. rer. nat. Dr. med. habil. Gerald Hüther, geb. 1951, ist Professor für Neurobiologie an der Psychiatrischen Klinik der Universität Göttingen. Zuvor, am Max-Planck-Institut für experimentelle Medizin, hat er sich mit Hirnentwicklungsstörungen und mit der langfristigen Modulation monoaminerger Systeme beschäftigt; als Heisenbergstipendiat hat er ein Labor für neurobiologische Grundlagenforschung aufgebaut.

This book contains peer-reviewed contributions presented at the 9th Meeting of the International Study Group of Tryptophan Research (ISTRY) held in Hamburg, October 1998. It provides a unique survey of the progress in tryptophan research and covers the research areas of psychiatry, neurology, pharmacology, toxicology, immunology, biochemistry, chemistry, food science and analytical chemistry.
The proceedings include contributions on basic research topics and clinical, nutritional or industrial applications. The book summarizes advances in the understanding of basic aspects of tryptophan metabolism and the role of many different tryptophan derivatives under physiological and pathological conditions as modulators of, e.g., nervous, immune, endocrine and metabolic regulation. Possible applications such as the therapeutic perspectives of tryptophan, 5-hydroxytryptophan and melatonin in medicine, their use as food supplements or animal feed, and the application of novel analytical methods in tryptophan research are described.

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Preface. Acknowledgements. 1: Psychiatry. 1.1. Basic Aspects. 1.2. Tryptophan Depletion. 1.3. Tryptophan and Melatonin Supplementation. 1.4. Appetite and Eating Disorders. 2: Neurology. 2.1. Basic Aspects. 2.2. Encephalopathy. 2.3. Migraine and Headache. 3: Pharmacology. 3.1. Neuropharmacology. 3.2. Clinical and Preclinical Pharmacology. 4: Medicinal and Pharmaceutical Chemistry. 4.1. Pathological Aspects. 4.2. Physiological Aspects. 4.3. Radical Scavenger and Antioxidants. 5: Toxicology. 5.1. Effects of Tryptophan Derived Compounds. 5.2. Effects of Toxins on Tryptophan Metabolism. 5.3. Eosinophilia-Myalgia Syndrome (EMS). 6: Immunology. 6.1. Basic Aspects. 6.2. Tryptophan Catabolism in Inflammatory Diseases. 7: Biochemistry. 7.1. Enzymology. 7.2. Pigmentation. 8: Agricultural and Food Sciences. 8.1. Food Science. 8.2. Nutrition. 8.3. Animal Nutrition. 9: Analytical Chemistry. 9.1. Applied Spectroscopy. 9.2. Chromatography and Biosensors.