Surface Modification of Polymeric Biomaterials

Applications of synthetic materials in medicine date back over 4000 year2. The Egyptians used linen as sutures. In the Roman Empire, gold was used in dentistry. Perhaps even earlier, ivory and bone may have been used in the body by practitioners of the healing arts. The historical origins of modem biomaterials science are also hard to precisely trace, but many of the ideas that define biomaterials as we know them today evolved in the late 1950s and early 1960s. Surface modification technology has played a prominent role in biomaterials science, and has paralleled the evolution of the modem field. In a symposium organized by the Artifical Heart Program of the NIH National Heart Institute and the Artificial Kidney program of the NIH National Institute of Arthritis and Metabolic Diseases, held in Atlantic City, New Jersey, in 1968, there were already a number of presentations on surface modification. Surface characterization at that time included scanning electron microscopy, ellipsometry, contact angle methods, and infrared internal reflection methods.

Proceedings of the American Chemical Society Division of Polymer Chemistry International Symposium held in Anaheim, California, April 2-6, 1995

Surface Modification of Polymers for Biomedical Applications: Chemical, Biological, and Surface Analytical Challenges.- A Creation of an Intelligent Surface - The Design of a Reactive Surface with Stimuli-Sensitivity toward Temperature and pH.- In Situ Surface Modification of Contact Lens Polymers.- Surface Modification of Segmented Polyurethaneureas via Oligomeric End Groups Incorporated During Synthesis.- XPS and SSIMS Characterization of Surfaces Modified by Plasma Deposited Oligo(glyme) Films.- Deposition of Fluorocarbon Films by Remote RF Glow Discharges.- Plasma Copolymerization of Tetrafluoroethylene and Chlorotrifluoroethylene.- Preparation of Plasma Polymerized Tetramethylhydrocyclotetrasiloxane Membrane on Microporous Hollow Fibers.- Plasma Treatments of Polymers by NH3-H2 RF Glow Discharges: Coupling Plasma and Surface Diagnostics.- Surface Characterization of Fiber-Supported Hydrogels.- XPS Analysis of Plasma-Treated Silicone Rubber.- Assaying for Primary Amines on Modified Polymer Surfaces Using TIRF Spectoscopy.- Surface Tension Analysis of PBT and PET Fibre-Based Leukodepletion Filters.- The Self-Assembly and Inhibition of Protein Adsorption by Thiolated Dextran Monolayers at Hydrophobic Metal Surfaces.- Hydrolysis of a Neutral Hydrogel and Biomolecule Attachment to Increase Cell Adhesion and Migration.- Surface Attachment of Functional Peptides by Electrochemical Polymerization.- Covalently Attached Thin Coatings Comprising Saccaride and Alkylene Oxide Segments.- Heparin Immobilization onto Sol-Gel Derived Organic-Inorganic Hybrid Network.- Covalent Surface Attachment of Polysaccharides via Bifunctional Epoxides.- Thermal Recovery of Cells Cultured on Poly(N-Isopropylacrylamide) Surface-Grafted Polystyrene Dishes.- Grafting of PEO via the WilliamsonEther Synthesis onto Polymeric Surfaces and Their Affinity for Proteins.- Four Protein-Friendly Approaches to Polymer Surface Metallization Using Monolayers of Gold Nanoparticles.- Contributors.