The Cytokine Network

Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy.They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. In the past five years, this bewildering array of more than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokinereceptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and targeted gene disruption to 'knock-out' production of individual cytokines in mice. It is also now clear that the pathophysiology of infectious, autoimmune and malignant disease can bepartially explained by the induction of cytokines and the subsequent cellular response. Viral homologues exist for many cytokines and receptors and genetic variations in cytokine production may influence response to pathogenic stimuli. Cytokine and cytokine antagonists have shown therapeuticpotential in a number of chronic and acute diseases. The Cytokine Network: Frontiers in Molecular Biology is not a survey of individual cytokines, but guides the reader through the latest research on the cytokine network as a whole covering genomics, signalling pathways, control of the immuneresponse, and therapeutics.

Rosen, et al: A Genomics Approach to Cytokine Discovery; Nelms: Cytokine Signal Transduction; Brennan and Feldmann: ; Romagnani: Cytokine and the Th1/Th2 Paradigm; Mantovani and Sozzani: Chemokines; Symons and Smith: Cytokines and Cytokine Receptors Encoded by Viruses; Duff: Genetic Variation in Cytokines and Relevance to Inflammation and Disease; Balkwill: Therapeutic Manipulation of the Cytokine Network.