Advanced Mechanical Models of DNA Elasticity

Adviser and Opponent of Graduate Dissertations in Central Research Institute for Fuel Apparatus, All-Russian Research Institute of Metrology, Leningrad Polytechnic Institute. He has contributed numerous articles to professional journals, and authored 4 monographs. He is also a member of International Society of Automation (recognition awards 1998-2012, ISA). His achievements include development of methods and concepts in micro elasticity, DNA elasticity modeling, atomic force microscopy, and information criterion of measurement uncertainty negligibility.

Advanced Mechanical Models of DNA Elasticity includes coverage on 17 different DNA models and the role of elasticity in biological functions with extensive references. The novel advanced helicoidal model described reflects the direct connection between the molecule helix structure and its specific properties, including nonlinear features and transitions. It provides an introduction to the state of the field of DNA mechanics, known and widely used models with their short analysis, as well as coverage on experimental methods and data, the influence of electrical, magnetic, ionic conditions on the persistence length, and dynamics with viscosity influence. It then addresses the need to understand the nature of the non-linear overstretching transition of DNA under force and why DNA has a negative twist-stretch coupling.

1. DNA Molecules Mechanical Properties and Models2. Force Application, Measurement, and Manipulation Accessories3. AFM with Higher Mode Oscillations and Higher Sensitivity4. Kinematics and Nonlinear Motion Transformation in Elastic Helicoids 5. Dynamics of the Elastic Systems with Helicoids6. Double-Stranded DNA Elasticity 7. DNA Elasticity with Transition