Translational Endocrinology of Bone
- 23 %

Translational Endocrinology of Bone

Reproduction, Metabolism, and the Central Nervous System
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Gerard Karsenty
936 g
284x217x2 mm

Karsenty, GerardGerard Karsenty received his MD and PhD from the University of Paris, France and completed his post-doctoral training at the University of Texas MD Anderson Cancer Center in 1990. His laboratory has studied every aspect of skeletal biology ranging from cell differentiation to function. His laboratory was the first one to decipher the molecular bases of osteoblast-specific gene expression, work that culminated in the identification of Runx2 as the master gene of osteoblast differentiation. The overarching assumption of Dr. Karsenty's work is that the appearance of bone during evolution has profoundly changed the physiology of animals because of the energetic cost that bone growth entails. Thus, over the last 10 years, his group has explored the hypothesis that the control of bone mass and energy metabolism must be coordinated and that this coordination is done, in large part, by hormones like leptin and osteocalcin that appear during evolution with bone. His lab has explored every aspect of this hypothesis through genetic and molecular means. Concurrent with this research, the Karsenty lab is exploring whether there are additional connections between bone physiology and the function of other organs such as fertility. This work culminated in the discovery that bone, via osteocalcin, regulates testosterone production.
The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology.

Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions

Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases.

Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles
1. Introduction

2. Bone Remodelling & Regulation

3. Food Intake of Bone Formation

4. Central Control of Bone Mass

5. Neuropeptide Y and Bone Formation 6. Serotonin: The Central Link between Bone Mass and Energy Metabolism

6. Gut Serotonin Bone Formation

7. Gut Serotonin and Osteoporosis

8. Regulation of Bone Resoprtion by PPARGamma

10. Regulation of Energy Metabolism by Bone

11. Bone Marrow Fat and Bone Mass

12. Bone Mass and Energy Metabolism in Humans

13. Regulation of Fertility by Bone

14. Molecular Signaling by Osteocalcin

15. Regulation of Phosphate Metabolism by FGF23

16. The Clinical Use of FGF 23

17. Transcriptional Regulation of the Endocrine Function of Bone

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