A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery
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Terry Kenakin
1501 g
287x219x25 mm

Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

  • Highlights changes surrounding the strategy of drug discovery to provide you with a comprehensive reference featuring advances in the methods involved in lead optimization and more effective drug discovery
  • Includes a new chapter on data-driven drug discovery in terms of the optimal design of pharmacological experiments to identify mechanism of action of new molecules
  • Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
Chapter 1 - What is Pharmacology?
Chapter 2 - How Different Tissues Process Drug Response
Chapter 3 - Drug Receptor Theory
Chapter 4 - Pharmacological Assay Formats: Binding
Chapter 5 - Agonists: The Measurement of Affinity and Efficacy in Functional Assays
Chapter 6 - Orthosteric Drug Antagonism
Chapter 7 - Allosteric Drug Interactions
Chapter 8 - Drug Discovery
Chapter 9 - Drug Development: Pharmacokinetics and Safety Pharmacology
Chapter 10 - Target-and System-based Strategies for Drug Discovery
Chapter 11 - Lead Optimization: Data-Driven Analysis
Chapter 12 - Statistics and Experimental Design
Chapter 13 - Selected Pharmacological Methods
Chapter 14 - Exercises in Pharmacodynamics and Pharmacokinetics
Glossary of Pharmacological Terms
Statistical Tables
Mathematical Fitting Functions

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